Overall The UPMC Hillman Cancer Center (HCC) at University of Pittsburgh is a matrix cancer center, currently led by Robert L. Ferris, MD, PhD, who has served as Director of HCC since 2017. With funding from the National Cancer Institute and other peer- and non-peer-reviewed sources, HCC conducts impactful basic, clinical/translational, and population science research that is changing the way we detect, diagnose, and treat cancer. Through our research and community outreach efforts, we address the needs and disparities of cancer patients and those who are at risk of developing cancer in our 29-county western Pennsylvania catchment area, and through our strong efforts in educating and training new cancer researchers and clinicians, we are ensuring that those needs will continue to be met in the years to come. HCC integrates the expertise and resources of the University of Pittsburgh, a top-5 institution in NIH funding, and UPMC, one of our nation?s largest health care systems, to provide our 280 members with state-of-the-art facilities and equipment, and numerous opportunities for interaction and collaboration. Organized into 7 research programs focused on Cancer Biology, Genome Stability, Cancer Virology, Cancer Immunology and Immunotherapy, Cancer Therapeutics, Cancer Epidemiology and Prevention, and Biobehavioral Cancer Control, our members published over 4,000 articles and enrolled more than 12,700 adult and pediatric patients onto interventional clinical trials from 2014-2018. These efforts were enabled by our 10 shared resources and extensive infrastructure for supporting clinical research at central academic and community network sites. HCC is guided by an experienced Senior Leadership Team of Deputy and Associate Directors who join Dr. Ferris in overseeing our science and operations. With input from the leaders of our research programs and other key HCC members, this team sets the vision and develops the strategic plan for our future development, which includes a new HCC-wide Administrative Core for supporting team science. Over the next 5 years, HCC aims to: 1) expand upon our existing scientific strengths; 2) augment our shared resources; 3) develop and implement strategies for reducing cancer-related health problems in our catchment area population; 4) increase transdisciplinary research in topics that include tumor genomics and precision medicine, translational cancer immunotherapy, and environmental factors that impact cancers in our catchment area, and cancer and aging; 5) increase focus on education and learning at all levels of training; 6) implement precision medicine; 7) seek institutional and philanthropic funding to support faculty recruitment and retention, and the facilities and shared resources needed to advance our research initiatives; and 8) continue to engage in the dynamic planning and decision-making process that was instituted by our new Director.

Public Health Relevance

Overall The mission of the UPMC Hillman Cancer Center (HCC) is to reduce the burden of cancer in western Pennsylvania and the nation through research, patient care, education and outreach. Since its founding in 1985, HCC has been at the forefront in discovery and advancement of scientific findings that have led to new strategies for preventing, detecting, diagnosing, and treating cancer, and for addressing the health-related needs and well-being of cancer patients and survivors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA047904-32
Application #
10024334
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Ptak, Krzysztof
Project Start
1997-09-10
Project End
2025-07-31
Budget Start
2020-09-04
Budget End
2021-07-31
Support Year
32
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Tong, Jingshan; Zheng, Xingnan; Tan, Xiao et al. (2018) Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res 78:4704-4715
Menk, Ashley V; Scharping, Nicole E; Rivadeneira, Dayana B et al. (2018) 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med 215:1091-1100
Wang, Yue; Wang, Zehua; Xu, Jieni et al. (2018) Systematic identification of non-coding pharmacogenomic landscape in cancer. Nat Commun 9:3192
Lee, Young-Sun; Lee, Dae-Hee; Choudry, Haroon A et al. (2018) Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis. Mol Cancer Res 16:1073-1076
Gough, Albert; Shun, Tong Ying; Taylor, D Lansing et al. (2018) Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies. Methods Mol Biol 1745:25-46
Fletcher, Rochelle; Wang, Yi-Jun; Schoen, Robert E et al. (2018) Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer 1869:138-148
Caves, Elizabeth A; Cook, Sarah A; Lee, Nara et al. (2018) Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere 3:
Saydmohammed, Manush; Vollmer, Laura L; Onuoha, Ezenwa O et al. (2018) A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules 23:
Li, Changfeng; Zhang, Ying; Cheng, Xing et al. (2018) PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Dev Cell 46:441-455.e8
Welty, Starr; Teng, Yaqun; Liang, Zhuobin et al. (2018) RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem 293:1353-1362

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