Career Enhancement and Related Activities A major strategic initiative for UPMC Hillman Cancer Center (HCC) is to develop a well-trained, diverse biomedical workforce through research education, training, and career-development activities that promote the understanding of the biology and treatment of cancer. To this end, the HCC Committee for Excellence in Cancer Education and Training (CECET) meets 4 times a year to review the breadth, depth, accessibility, and effectiveness of available education and training opportunities and to develop new programs as needed. CECET overseas an HCC investment of ~$1.4M/year in education and training. Our work is organized through three main specific aims designed to provide career enhancement opportunities across the biomedical training pipeline.
The first aim i s to educate and inspire high school and undergraduate students about careers in cancer research with a focus on serving underrepresented populations. The Hillman Academy has provided an 8-week summer internship introducing careers in cancer research to 433 high school students, including 175 (40%) underrepresented minority and disadvantaged (URM/DA) in our catchment area (CA). The Academy is supported by the Doris Duke Charitable Foundation, CURE and the Jack Kent Foundation, and the award of a new R25CA236620 allows an immediate 70% increase in the number of URM/DA students. This new R25CA236620 also provides support to improve the science literacy of our surrounding community by developing 1-day workshops that include hands-on activities, tours of facilities, and career seminars on cancer research.
Our second aim i s to encourage medical and doctoral students as well as clinical and postdoctoral fellows to pursue careers in cancer research. We have used HCC philanthropy to recruit the first class of Hillman Medical Student and Postdoctoral Fellows for Innovative Cancer Research. We have increased the number of NCI T32 training grants from 4 to 6 to support the cancer research focus of all CCSG programs. Our commitment to graduate student researcher (GSR) education is evidenced by our support of more GSRs than any other Pitt SOM Institute or Department. At the request of the newly formed HCC postdoctoral association, we have established a new grant writing class that tailors K99 R00 applications to the NCI. This initiative builds on previous F30, F31, F99 K00 and K00 R01 successes. We will extend our Hillman Fellows for Innovative Cancer Research program into a new ?Bridge to Faculty? positions that will guarantee faculty positions when key metrics are attained.
Our third aim i s to enhance the professional growth of faculty through an extensive, multi-faceted faculty mentorship program that eliminates barriers to innovative cancer research and strengthens R01 applications to the NCI. We will also increase efforts across our network to ensure equal access of our health care providers to exceptional cancer education and training programs, such as Accountability for Cancer Care through Undoing Racism and Equity and AP-POWER (R25CA148050).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA047904-32
Application #
10024336
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-10
Project End
2025-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
32
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Qin, Ye; Vasilatos, Shauna N; Chen, Lin et al. (2018) Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene :
Steinman, Justin; Epperly, Michael; Hou, Wen et al. (2018) Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res 189:68-83
Yockey, Laura J; Jurado, Kellie A; Arora, Nitin et al. (2018) Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol 3:
Chen, Jingci; Nagle, Alison M; Wang, Yu-Fen et al. (2018) Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. J Biol Chem 293:3700-3709
Diaz-Perez, Julio A; Killeen, Meaghan E; Yang, Yin et al. (2018) Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis. J Invest Dermatol 138:2595-2605
Evdokimova, Viktoria N; Gandhi, Manoj; Nikitski, Alyaksandr V et al. (2018) Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements. Oncotarget 9:13612-13622
Bissel, Stephanie J; Gurnsey, Kate; Jedema, Hank P et al. (2018) Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. Retrovirology 15:17
Knickelbein, Kyle; Tong, Jingshan; Chen, Dongshi et al. (2018) Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene 37:4599-4610
Redner, Robert L; Beumer, Jan H; Kropf, Patricia et al. (2018) A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia. Leuk Lymphoma 59:2595-2601
Ancevski Hunter, Katerina; Socinski, Mark A; Villaruz, Liza C (2018) PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer. Mol Diagn Ther 22:1-10

Showing the most recent 10 out of 1187 publications