This grant application is the renewal of the Cancer Center Support Grant of the Lombardi Cancer Center (LCC) the Georgetown University Medical Center. The major focus of the LCC is to bring an increased understanding f the cellular and molecular biology of the malignant process to the point where it can improve diagnosis, prognostication, treatment, and prevention of cancer. Organized as a traditional matrix center, the LCC has continued to be an NCI- designated Comprehensive Cancer Center since 1990. The current application represents a summary f cancer research activities conducted under the aegis of the LCC. The application consists of eight research programs: Breast Cancer, Cancer Prevention and Control, Developmental Therapeutics, Experimental Hematology/Lymphoma, Growth Regulation, Invasion and Metastasis, Neuro-Oncology, and Radiation Biology; one developing program: Cancer Genetics; and nine shared resources: Animal Research Resource, Biostatistics, Clinical Research Management Office, Flow Cytometry/Cell Sorting, Histopathology and Tissue Resource, Macromolecular Synthesis and Sequencing, Microscopy and Imaging, Research Computing, and Tissue Culture. Since the last peer review site visit, the Cancer Center has undergone substantial expansion and reorganization to further improve its effectiveness. Changes have been made to programs and shared resources, as well as in Cancer Center leadership and space allocated to the research mission. In the last three years, there has also been substantial progress and investment made in the translational and clinical research activities of the LCC, including the recruitment of important clinical research and biostatistics leaders, and a major reorganization of functions and activities which promote translationaI and clinical investigations. The development of clinical and laboratory search in cancer continues to be the highest-stated priority of the Georgetown University Medical Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Georgetown University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Fu, Ying; Silverstein, Shana; McCutcheon, Justine N et al. (2018) An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice. Hepatology 67:159-170
Pohlmann, Paula R; Isaacs, Claudine (2018) Extended Adjuvant Endocrine Therapy for Postmenopausal Women: Treating Many to Benefit a Few. J Natl Cancer Inst 110:
Xiao, David; Zheng, Chaoyi; Jindal, Manila et al. (2018) Medicaid Expansion and Disparity Reduction in Surgical Cancer Care at High-Quality Hospitals. J Am Coll Surg 226:22-29
Stires, Hillary; Heckler, Mary M; Fu, Xiaoyong et al. (2018) Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities. Mol Cell Endocrinol 471:105-117
Zheng, Wenjie; Wu, Xiuhua; Goudarzi, Maryam et al. (2018) Metabolomic alterations associated with Beh├žet's disease. Arthritis Res Ther 20:214
Kozlik, Petr; Goldman, Radoslav; Sanda, Miloslav (2018) Hydrophilic interaction liquid chromatography in the separation of glycopeptides and their isomers. Anal Bioanal Chem 410:5001-5008
Bluethmann, Shirley M; Sciamanna, Christopher N; Winkels, Renate M et al. (2018) Healthy Living After Cancer Treatment: Considerations for Clinical and Community Practice. Am J Lifestyle Med 12:215-219
Getnet, Derese; Gautam, Aarti; Kumar, Raina et al. (2018) Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a case for Novel Signatures for Asymptomatic Nerve Agent Exposure. Appl Environ Microbiol :
Aldeghaither, Dalal S; Zahavi, David J; Murray, Joseph C et al. (2018) A Mechanism of Resistance to Antibody-Targeted Immune Attack. Cancer Immunol Res :
Graves, Kristi D; Hall, Michael J; Tercyak, Kenneth P (2018) Introduction to the Special Issue on Clinical and Public Health Genomics: Opportunities for translational behavioral medicine research, practice, and policy. Transl Behav Med 8:4-6

Showing the most recent 10 out of 1120 publications