The Cancer Prevention and Population Science (CPPS) Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship. Research in the CPPS Program is organized in a cancer control conceptual model that progresses from discovery to intervention to dissemination. The program has three scientific goals: 1) Identify determinants, biomarkers of risk and prognosis, genetics, and lifestyle factors to enhance cancer screening and treatment outcomes;2) Use laboratory-based molecular and experimental cancer prevention strategies to disrupt pathogenesis using synthetic and natural compounds, and lifestyle changes, translating preclinical evaluation of chemopreventive agents to interventional trials;and 3) Reduce the Latino cancer burden through community-based research, testing interventions addressing highly prevalent and disproportionate cancers and their risk factors in the Latino population. The 22 CPPS members include faculty from 11 academic departments and two schools at the University of Texas Health Science Center at San Antonio (UTHSCSA) and one at the University of Texas at San Antonio (UTSA). The CPPS Program has $7,154,300 in peer-revieyved cancer-related funding representing 30 peer-reviewed grants. Of this total, $2,438,763 (14 grants) are funded by the NCI. Over the last funding period, the CPPS Program has 186 peer-reviewed cancer related publications, of which 51 (28%) are intra-programmatic and 27 (15%) are inter-programmatic collaborations, with 78% of publications in collaboration with other institutions.

Public Health Relevance

The Cancer Therapy &Research Center's Cancer Prevention and Population Science Program conducts collaborative, hypothesis-driven and evidence-based, translational cancer prevention and control research that covers the cancer continuum primary prevention, early detection, laboratory research, clinical trials and applications, diagnosis and treatment, quality of life, and survivorship, with a sustained focus on the CTRC catchment area.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA054174-20
Application #
8758355
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M3))
Project Start
1997-08-01
Project End
2019-07-31
Budget Start
2014-09-16
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$58,464
Indirect Cost
$39,733
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Chalela, Patricia; Muñoz, Edgar; Gallion, Kipling J et al. (2018) Empowering Latina breast cancer patients to make informed decisions about clinical trials: a pilot study. Transl Behav Med 8:439-449
Chalela, P; Munoz, E; Inupakutika, D et al. (2018) Improving adherence to endocrine hormonal therapy among breast cancer patients: Study protocol for a randomized controlled trial. Contemp Clin Trials Commun 12:109-115
Liu, Jinyou; Sareddy, Gangadhara R; Zhou, Mei et al. (2018) Differential Effects of Estrogen Receptor ? Isoforms on Glioblastoma Progression. Cancer Res 78:3176-3189
Weiner, Marc; Gelfond, Jon; Johnson-Pais, Teresa L et al. (2018) Elevated Plasma Moxifloxacin Concentrations and SLCO1B1 g.-11187G>A Polymorphism in Adults with Pulmonary Tuberculosis. Antimicrob Agents Chemother 62:
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Chakravarthy, Divya; Muñoz, Amanda R; Su, Angel et al. (2018) Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. Cancer Lett 419:103-115
Zhu, Haiyan; Gu, Xiang; Xia, Lu et al. (2018) A Novel TGF? Trap Blocks Chemotherapeutics-Induced TGF?1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers. Clin Cancer Res 24:2780-2793
Cooney, Jeffrey D; Lin, An-Ping; Jiang, Daifeng et al. (2018) Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3K? in Mature B-cell Malignancies. Clin Cancer Res 24:1103-1113
Azpurua, Jorge; Mahoney, Rebekah E; Eaton, Benjamin A (2018) Transcriptomics of aged Drosophila motor neurons reveals a matrix metalloproteinase that impairs motor function. Aging Cell 17:
Bandyopadhyay, Abhik; Favours, Edward; Phelps, Doris A et al. (2018) Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models. Pediatr Blood Cancer 65:

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