CANCER CELL BIOLOGY AND SIGNALING PROGRAMThe Cancer Cell Biology and Signaling Program is comprised of nineteen investigators from sixdepartments. The program mission is to elucidate the role of cell signaling in regulating cell growth,differentiation, and apoptosis. The program focuses on three major areas of research: 1) understanding themolecular mechanisms involved in the regulation of cell growth and differentiation with an emphasis on therole of tyrosine kinase and G protein-coupled receptor signaling pathways; 2) elucidating the molecularmechanisms regulating cell apoptosis; and 3) addressing the role of the extracellular matrix in regulatingcell growth and migration.An important scientific goal of this program is to integrate fundamental studies on the mechanisms thatregulate cell growth, differentiation, and apoptosis with the translational research efforts at the KCC. Thisshould result in a better understanding of the biology of cancer and also in the translation of basic researchinto novel therapeutic strategies for the treatment of cancer. All program members are NIH funded. Theycurrently have $2.6 million of NCI support and $9.8 million of total, peer-reviewed support. Programmembers published a total of 320 cancer-relevant manuscripts (8% intra-programmatic and 13% interprogrammatic)during the last grant period.
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