LABORATORY ANIMAL SHARED RESOURCEThe primary purpose of the Laboratory Animal Shared Resource is to provide the resources andenvironment with which animals models of cancer can be created and analyzed for the KimmelComprehensive Cancer Center. This shared resource provides housing and high quality maintenance andcare for laboratory animals. The facility also provides technical expertise in small animal surgery,administration of chemical and radiological reagents. A critical component of the facility is the maintenanceof a high quality barrier facility to generate a specific pathogen free environment that ensures the accurateinterpretation of experimental results. The in-colony health surveillance program ensures that fidelity of thefacility. The Animal Shared Resource has maintained full AAALAC accreditation since 1977. The facility isoperated as a partial barrier system in which all animals are housed in sterile microisolator cages. Thefacility is composed of 29 animal rooms, along with the requisite cage and food storage area, a dedicatednecropsy room, and a tunnel cage washer. The shared resource has consistently maintained the highestlevel of expertise and proficiency greatly enhancing the work of the cancer center members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA056036-09
Application #
7712915
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-09-05
Project End
2013-05-31
Budget Start
2008-09-05
Budget End
2009-05-31
Support Year
9
Fiscal Year
2008
Total Cost
$131,828
Indirect Cost
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C et al. (2018) Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest 128:341-358
Garcia, Samantha A; Lebrun, Aurore; Kean, Rhonda B et al. (2018) Clearance of attenuated rabies virus from brain tissues is required for long-term protection against CNS challenge with a pathogenic variant. J Neurovirol 24:606-615
Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3
Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469
Liao, Lili; Liu, Zongzhi Z; Langbein, Lauren et al. (2018) Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Elife 7:
Heeke, Arielle L; Pishvaian, Michael J; Lynce, Filipa et al. (2018) Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types. JCO Precis Oncol 2018:
Parent, Kristin N; Schrad, Jason R; Cingolani, Gino (2018) Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy. Viruses 10:
Rappaport, Jeffrey A; Waldman, Scott A (2018) The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Front Oncol 8:299

Showing the most recent 10 out of 807 publications