Among the keys to deciphering normal physiological processes and their derangements in neoplasia are an understanding of the relationship in spatial and temporal terms of different cellular components to each other, and the related ability to correlate structure with function. Providing these capabilities of visualization is the goal of the KCC Bioimaging Facility/Shared Resource by having available powerful, reliable, and readily accessible light microscopic image acquisition and analysis capabilities for KCC investigators. The Facility is Cancer Center-managed and operates with well-trained staff and a faculty supervisor. Dr. James Keen, and provides training in operation of all instruments as well as consultation in operation, methodology, experimental approach, and interpretation. It is open for scheduled use at any time by trained investigators, or the Facility operator can perform imaging and analysis with laboratory personnel. Through the operation of this Shared Resource, individual KCC investigators are assured of state-of-the-art and reliable facilities operated with a high degree of technical expertise, and are relieved of the obligation for substantial outlay for equipment, maintenance and personnel training. The facility has provided service for more than 90 laboratories and several hundred individuals during the past award period, of which more than 80% are Cancer Center members. Major support for the Facility has been derived from successful competition for extramural funding, from institutional and Cancer Center sources, and from user chargebacks tied to services rendered.
The Kimmel Cancer Center Bioimaging Facility provides investigators with the capability to visualize cells and structures within living and fixed cells at the light microscope level. By being able to determine the location and distribution of cellular components in time and space in normal and neoplastic samples, investigators can gain new information about how cancer cells differ from normal ones, and test hypotheses about cancer causation and progression.
|Liao, Lili; Liu, Zongzhi Z; Langbein, Lauren et al. (2018) Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Elife 7:|
|Heeke, Arielle L; Pishvaian, Michael J; Lynce, Filipa et al. (2018) Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types. JCO Precis Oncol 2018:|
|Parent, Kristin N; Schrad, Jason R; Cingolani, Gino (2018) Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy. Viruses 10:|
|Rappaport, Jeffrey A; Waldman, Scott A (2018) The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Front Oncol 8:299|
|Pandya, Kalgi D; Palomo-Caturla, Isabel; Walker, Justin A et al. (2018) An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid. J Immunol 200:4078-4084|
|Hussain, Maha; Daignault-Newton, Stephanie; Twardowski, Przemyslaw W et al. (2018) Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012. J Clin Oncol 36:991-999|
|Shafi, Ayesha A; Schiewer, Matthew J; de Leeuw, Renée et al. (2018) Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response. Eur Urol Oncol 1:325-337|
|Meyer, Sara E; Muench, David E; Rogers, Andrew M et al. (2018) miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med 215:2115-2136|
|Mazina, Olga M; Mazin, Alexander V (2018) Reconstituting the 4-Strand DNA Strand Exchange. Methods Enzymol 600:285-305|
|Magee, Michael S; Abraham, Tara S; Baybutt, Trevor R et al. (2018) Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer Immunol Res 6:509-516|
Showing the most recent 10 out of 807 publications