The mission of the Sidney Kimmel Cancer Center Translational Pathology Shared Resource (TPSR) is to serve as a biomedical research resource supporting novel cancer research for the SKCC's basic, clinical, and translational members. The TPSR provides immediate, single-portal access to pathology and informatics faculty expertise and technical support, including a comprehensive range of high-quality pathology and informatics services coupled with critical access to unique banked tissue collections. The TPSR was founded in 2000 and has been continuously funded by the NCI since 2001. The former Informatics Shared Resource (ISR) was integrated into the TPSR during the current project period, due to the close working relationship and mutual focus of informatics with pathology services. Stephen Peiper, MD, oversees the combined Shared Resource. Wei Jiang, MD, PhD, and Haifeng Yang, PhD, serve as Pathology Co-Directors under the direction of Dr. Peiper. Zhijiu Zhong, MD, MS, is an experienced facility manager responsible for the day-to-day operation of the TPSR. The TPSR has dedicated laboratory space in the centrally located Bluemle Life Sciences Building (BLSB). In addition, there is connecting office space for consultation on histology and informatics needs. Current TPSR goals include: 1) Provide data, specimens, and technology to enhance all aspects of oncology research; 2) Offer a full range of exceptional histopathology services: IHC (including multi- parameter), ISH, automation, laser capture microdissection, tissue array creation, and digital pathology with high res image analysis; 3) Give access to a CAP-accredited biorepository; 4) Provide biomedical research informatics tools for facile interrogation of a well-developed data warehouse.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA056036-19
Application #
9492091
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
19
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Peng, Weidan; Furuuchi, Narumi; Aslanukova, Ludmila et al. (2018) Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development. Mol Cell Biol 38:
Waldman, Scott A; Camilleri, Michael (2018) Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut 67:1543-1552
Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136
Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C et al. (2018) Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest 128:341-358
Garcia, Samantha A; Lebrun, Aurore; Kean, Rhonda B et al. (2018) Clearance of attenuated rabies virus from brain tissues is required for long-term protection against CNS challenge with a pathogenic variant. J Neurovirol 24:606-615
Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3
Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469

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