CANCER CELL BIOLOGY AND SIGNALING PROGRAM (CCBS) ABSTRACT: The purpose of CCBS, a Discipline-Based Program, is to make fundamental mechanistic discoveries into signaling pathways that are dysregulated in human cancer and to translate findings into new treatment opportunities. Common themes are to: 1) Integrate genomic, biochemical and functional analyses to determine the role and dysregulation of signaling pathways in relevant cancer models; 2) Identify mechanisms of resistance to targeted inhibitors; and 3) Characterize the role of the stroma in the tumor microenvironment. Current specific aims are:
Aim 1 : Discover mechanisms regulating cell growth & metastasis by heterotrimeric and monomeric GTPases Aim 2: Characterize the role of the tumor microenvironment in regulating protein kinase signaling pathways and metabolism Aim 3: Identify the regulation and role of inflammation and cytokine signaling The CCBS Program has 42 members that include basic scientists, clinical researchers, and population scientists that have made high-impact discoveries at the bench and in the clinic. Members generated 776 publications, an increase of +19.4% over the prior project period. Of these, 135(17.4%) were intra- programmatic, an increase of +58.2%; 164 were inter-programmatic (21.1%). Overall impact has improved with 7.5% appearing in journals with an impact factor >10 and an average impact factor of 5.6. In 2016, SKCC also began to track collaborations with authors from other NCI-designated Cancer Centers; at present, 34.2% of CCBS Program publications were in collaboration with authors from other NCI-designated Centers. The overall impact of CCBS is illustrated by the number of high-impact fundamental discoveries that have been published in the last funding cycle, including in Cell, PNAS, JAMA, J. Clin Invest., J. Clin Oncol., Nature and Nature Comm. In the last funding period, CCBS members were productive in securing funding. Notably, the mechanism for calculating total and direct costs has changed since the last CCSG review, now requiring exclusion of funding sources that were allowable in the last review. Furthermore, SKCC was last reviewed during the peak of ARRA funding. Despite these barriers in comparing current funding totals versus the last review, CCBS remains strong. Total cancer relevant funding increased from $13.7M to $17.1M total costs (+29.0 %) with direct costs also increasing from $9.4M to $12.2 (+29.8%). Annual peer-reviewed funding is steady from the last review at $11.7M total/ $7.7M direct, with 27.2 % of peer-reviewed funding derived from NCI, and 32.8% from combined federal cancer-dedicated peer review sources (NCI + Department of Defense Cancer Programs).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-21
Application #
9956995
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
21
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Rappaport, Jeffrey A; Waldman, Scott A (2018) The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Front Oncol 8:299
Pandya, Kalgi D; Palomo-Caturla, Isabel; Walker, Justin A et al. (2018) An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid. J Immunol 200:4078-4084
Hussain, Maha; Daignault-Newton, Stephanie; Twardowski, Przemyslaw W et al. (2018) Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012. J Clin Oncol 36:991-999
Shafi, Ayesha A; Schiewer, Matthew J; de Leeuw, Renée et al. (2018) Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response. Eur Urol Oncol 1:325-337
Meyer, Sara E; Muench, David E; Rogers, Andrew M et al. (2018) miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med 215:2115-2136
Mazina, Olga M; Mazin, Alexander V (2018) Reconstituting the 4-Strand DNA Strand Exchange. Methods Enzymol 600:285-305
Magee, Michael S; Abraham, Tara S; Baybutt, Trevor R et al. (2018) Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer Immunol Res 6:509-516
Chervoneva, Inna; Freydin, Boris; Hyslop, Terry et al. (2018) Modeling qRT-PCR dynamics with application to cancer biomarker quantification. Stat Methods Med Res 27:2581-2595
Capparelli, Claudia; Purwin, Timothy J; Heilman, Shea A et al. (2018) ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma. Cancer Res 78:5680-5693
Nevler, Avinoam; Muller, Alexander J; Cozzitorto, Joseph A et al. (2018) A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. J Am Coll Surg 226:596-603

Showing the most recent 10 out of 807 publications