The Genomics core is a new shared resource facility that brings together into one core, the capabilities of Microarray and Genotyping cores along with the DMA sequencing services previously offered by the Northwestern Biotechnology Laboratory. The facility provides the Robert H. Lurie Comprehensive Cancer Center members, NU researchers, and external users access to gene expression profiling using three platforms; genotyping and SNP analysis using three different technologies; automated high-throughput DNA extraction and DNA sequencing services. This consolidation produces a more efficient and cost effective operation. The core is staffed by the director, 5 technicians and a financial assistant. The core houses 8 major instruments, including a Centra Systems AUTOPURE LS, Illumina BeadChip 500GXDW system, Affymetrix GeneChip instrument system, ABI 7900HT, 400XL ScanArray, MicroGridll, ABI 3130x1 and an 3730 DNA analyzer. The Genomics core collaborates closely with the bioinformatics core and plans to increase its collaboration with pathology core as it consolidates its services into this new operation. In addition, the genomics core will continue sponsoring educational talks and workshops to help maintain a high level of knowledge amongst Cancer Center investigators regarding state-of-the-art genomics research technologies to help facilitate their research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA060553-15
Application #
7666681
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
15
Fiscal Year
2008
Total Cost
$186,483
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Buglak, Nicholas E; Jiang, Wulin; Bahnson, Edward S M (2018) Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats. Redox Biol 19:166-178
Yang, Ruiguo; LemaƮtre, Vincent; Huang, Changjin et al. (2018) Monoclonal Cell Line Generation and CRISPR/Cas9 Manipulation via Single-Cell Electroporation. Small 14:e1702495
Takahashi, Satoe; Sun, Willy; Zhou, Yingjie et al. (2018) Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells. Front Cell Neurosci 12:211
Zheng, Jianbin; Chen, Long; Skinner, Owen S et al. (2018) ?-Glucocerebrosidase Modulators Promote Dimerization of ?-Glucocerebrosidase and Reveal an Allosteric Binding Site. J Am Chem Soc 140:5914-5924
Kenney, Grace E; Dassama, Laura M K; Pandelia, Maria-Eirini et al. (2018) The biosynthesis of methanobactin. Science 359:1411-1416
Joyce, Brian T; Zheng, Yinan; Zhang, Zhou et al. (2018) miRNA-Processing Gene Methylation and Cancer Risk. Cancer Epidemiol Biomarkers Prev 27:550-557
Chu, Lan H; Indramohan, Mohanalaxmi; Ratsimandresy, Rojo A et al. (2018) The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun 9:996
Symes, Yael R; Barrington, Clare; Austin, Jane et al. (2018) Advice to patients undergoing stem cell transplant: Content analysis of survivor peer support narratives. J Health Psychol 23:818-828
Lewis, Phillip L; Green, Richard M; Shah, Ramille N (2018) 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomater 69:63-70
Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii et al. (2018) 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs 29:717-724

Showing the most recent 10 out of 1972 publications