The Robert H. Lurie Comprehensive Cancer Center of Northwestern University is an NCI-designated, university based, matrix cancer center conducting a broad range of multidisciplinary clinical, laboratory and population science research. The Lurie Cancer Center integrates the expertise and resources of the Feinberg School of Medicine (Chicago Campus) and its affiliated hospitals along with those of departments located on the University's Evanston Campus. Established in 1974, the Lurie Cancer Center functions as a full organizational unit with the status of a department of the Feinberg School of Medicine. Since its inception, the Lurie Cancer Center has been dedicated to the process of discovery, advancing medical knowledge and providing compassionate, state-of-the-art cancer care, and conducting community outreach and survivorship programs as reflected in the following goals: 1. To conduct and support cancer research and to integrate cancer-related research throughout the University;2. To coordinate and integrate cancer-related activities of the University including community outreach initiatives;3. To develop and conduct cancer education programs;4. To promote and participate in state-of-the-art care of cancer patients at the affiliated hospitals, and 5. To develop and implement initiatives in cancer prevention and control research. These goals are accomplished through the activities of 9 established programs and 15 shared resources. Programs: 1. Cancer Cell Biology; 2. Tumor Invasion, Metastasis, &Angiogenesis; 3. Signal Transduction in Cancer;4. Cancer and Physical Sciences;5. Women's Cancer;6. Translational Research in Solid Tumors;7. Hematologic Malignancies;8. Cancer Prevention;and 9. Cancer Control and Survivorship. Shared Resources: 1. Cell Imaging;2. Developmental Therapeutics;3. Flow Cytometry;4. High Throughput; 5. Keck Biophysics;6. Medicinal &Synthetic Chemistry Core; 7. Molecular &Translational Imaging; 8. Mouse Phenotyping; 9. Pathology Core;10. Structural Biology;11. Transgenic and Targeted Mutagenesis Laboratory;12. Outcomes Measurement &Survey Core;13. Cancer Informatics;14. Biostatistics;and 15. Clinical Research Office. This competing renewal application is being submitted as a Consortium/Partnership Application including the main institution and Ann &Robert H. Lurie Children's Hospital of Chicago. Cancer Center members at the partner institution are fully integrated with those at the main campuses of the University and together contribute to the ongoing progress of the Center in achieving its mission, goals and objectives. This Cancer Center Support Grant is requested to provide support for the critical infrastructure and shared resources needed by our scientific program investigators to seek methods for the prevention, diagnosis, treatment and rehabilitation of cancer.

Public Health Relevance

This Cancer Center Support Grant is requested to provide support for the critical infrastructure and shared resources needed by our scientific program investigators to seek methods forthe prevention, diagnosis, treatment and rehabilitation of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA060553-20
Application #
8735081
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ptak, Krzysztof
Project Start
1997-08-01
Project End
2018-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$4,686,132
Indirect Cost
$1,678,059
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Stack, Trevor; Vahabikashi, Amir; Johnson, Mark et al. (2018) Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. J Biomed Mater Res A 106:1771-1779
Blair, Kris M; Mears, Kevin S; Taylor, Jennifer A et al. (2018) The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton. Mol Microbiol 110:114-127
Karabin, Nicholas B; Allen, Sean; Kwon, Ha-Kyung et al. (2018) Sustained micellar delivery via inducible transitions in nanostructure morphology. Nat Commun 9:624
Welch, Whitney A; Spring, Bonnie; Phillips, Siobhan M et al. (2018) Moderating Effects of Weather-Related Factors on a Physical Activity Intervention. Am J Prev Med 54:e83-e89
Kaplan, Nihal; Ventrella, Rosa; Peng, Han et al. (2018) EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Invest Ophthalmol Vis Sci 59:393-406
Kenig-Kozlovsky, Yael; Scott, Rizaldy P; Onay, Tuncer et al. (2018) Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol 29:1097-1107
Zhang, Angelica; Veesenmeyer, Jeffrey L; Hauser, Alan R (2018) Phosphatidylinositol 4,5-Bisphosphate-Dependent Oligomerization of the Pseudomonas aeruginosa Cytotoxin ExoU. Infect Immun 86:
Ting, See-Yeun; Bosch, Dustin E; Mangiameli, Sarah M et al. (2018) Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins. Cell 175:1380-1392.e14
Nahum-Shani, Inbal; Smith, Shawna N; Spring, Bonnie J et al. (2018) Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health: Key Components and Design Principles for Ongoing Health Behavior Support. Ann Behav Med 52:446-462
Kang, Hong-Jun; Song, Ha Yong; Ahmed, Mohamed A et al. (2018) NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity. Free Radic Biol Med 126:358-371

Showing the most recent 10 out of 1972 publications