The Mouse Histology and Phenotyping Laboratory (MHPL) provides the Northwestern University research community with histopathology assessment of murine tissues by trained pathologists and comprehensive histology services performed by expert histotechnologists. In addition, training is provided for investigators to learn to detect gross anomalies in rodents, to harvest tissue from various organ systems and to perform immunohistochemical and special histological stains on tissue sections generated by the MHPL. The MHPL was developed to fulfill a need by the investigative community to assist with the analysis of new murine models, to leverage the expertise of pathologists in the histopathological assessment of tissue anomalies and neoplasms, and to increase the likelihood of extracting meaningful phenotypic information to guide future investigations. Murine tissue has histological characteristics distinct from human tissue and therefore accurate interpretation requires microscopic examination by.pathologists with an understanding of disease pathobiology, rodent histopathology and murine development. Moreover, tissue isolation, processing, and sectioning often require the involvement of highly skilled histotechnologists, especially when embryonic lethal phenotypes or complex developmental abnormalities are to be studied. The MHPL is directed by an anatomic pathologist and neuropathologist with more than twenty years of experience in diagnosing human tumors and developmental abnormalities. He has equally extensive training in rodent adult and developmental pathobiology and histopathology. Other members ofthe MHPL staff include a second fulltime associate pathologist, three full-time ASCP certified histotechnologists, two part-time histotechnologists and two part-time technical/administrative assistants. Together, this team provides a broad range of technical and diagnostic services to investigators throughout the Northwestern University research enterprise in a high-volume and fast-paced environment. These comprehensive histopathology support services enhance the ability of our Cancer Center investigators to characterize viable and embryonic lethal mouse models and to develop and analyze new in vivo model systems to study cancer biology.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Buglak, Nicholas E; Jiang, Wulin; Bahnson, Edward S M (2018) Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats. Redox Biol 19:166-178
Yang, Ruiguo; LemaƮtre, Vincent; Huang, Changjin et al. (2018) Monoclonal Cell Line Generation and CRISPR/Cas9 Manipulation via Single-Cell Electroporation. Small 14:e1702495
Takahashi, Satoe; Sun, Willy; Zhou, Yingjie et al. (2018) Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells. Front Cell Neurosci 12:211
Zheng, Jianbin; Chen, Long; Skinner, Owen S et al. (2018) ?-Glucocerebrosidase Modulators Promote Dimerization of ?-Glucocerebrosidase and Reveal an Allosteric Binding Site. J Am Chem Soc 140:5914-5924
Kenney, Grace E; Dassama, Laura M K; Pandelia, Maria-Eirini et al. (2018) The biosynthesis of methanobactin. Science 359:1411-1416
Joyce, Brian T; Zheng, Yinan; Zhang, Zhou et al. (2018) miRNA-Processing Gene Methylation and Cancer Risk. Cancer Epidemiol Biomarkers Prev 27:550-557
Chu, Lan H; Indramohan, Mohanalaxmi; Ratsimandresy, Rojo A et al. (2018) The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun 9:996
Symes, Yael R; Barrington, Clare; Austin, Jane et al. (2018) Advice to patients undergoing stem cell transplant: Content analysis of survivor peer support narratives. J Health Psychol 23:818-828
Lewis, Phillip L; Green, Richard M; Shah, Ramille N (2018) 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomater 69:63-70
Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii et al. (2018) 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs 29:717-724

Showing the most recent 10 out of 1972 publications