The Biostatistics Shared Resource (BSR) assists clinical, epidemiologic, and basic science investigators within the Cancer Center with study design, dat analysis, and linkage of clinical, epidemiologic, and laboratory data. The BSR plays an active role in the design of new studies with a concentration in cancer etiology, genetics, detection, and prevention. Major emphasis is placed on developing and maintaining statistical quality control procedures. The Shared Resource provides linkage of laboratory tumor data, clinical information, demographic information, and follow-up data. Statistical consultations involve participation in the design of the research, quantitative description of the protocol, calculation of sample size requirements, and description of statistical methods. Since 1998, the Biostatistics Shared Resource has devoted 36% of service to peer-reviewed funded projects, 29% to educational efforts and development of statistical resources, 11% to peer-reviewed funded projects, 29% to educational efforts and development of statistical resources, 11% to peer-reviewed agency submissions, 10% to project development, 10% to CTPRMC-approved clinical trials, and 4% of service to non-Cancer Center usage. Assistance has been provided to Cancer Center investigators in the following programs: Clinical Oncology, Epidemiology, Carcinogenesis, Photomedicine, Growth Factors and Signaling, Structural Molecular Biology, and Virology. In summary, the Biostatistics Shared Resource has continued to contribute heavily to research efforts at the Chao Family Comprehensive Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA062203-09
Application #
6660919
Study Section
Project Start
2002-09-19
Project End
2003-02-28
Budget Start
Budget End
Support Year
9
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Wang, Yajun; Ngor, Arlene K; Nikoomanzar, Ali et al. (2018) Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun 9:5067
Qiu, Xiaolong; Lombardo, Jeremy A; Westerhof, Trisha M et al. (2018) Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip 18:2776-2786
Patterson, Kurt; Yu, James; Landberg, Jenny et al. (2018) Functional genomics for the oleaginous yeast Yarrowia lipolytica. Metab Eng 48:184-196
Lee, J Scott; Roberts, Andrew; Juarez, Dennis et al. (2018) Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med 10:
Sierra, Robert A; Hoverter, Nathan P; Ramirez, Ricardo N et al. (2018) TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development 145:
Maciejewski, Sonia; Ullmer, Wendy; Semler, Bert L (2018) VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology 516:139-146
Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99
Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433
Wang, Xiaolin; Zhao, Da; Phan, Duc T T et al. (2018) A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip 18:2167-2177
Flather, Dylan; Nguyen, Joseph H C; Semler, Bert L et al. (2018) Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog 14:e1007277

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