The central theme of the Developmental Biology (DB) Program is that cancer is often the result of corrupted developmental regulatory networks. We strive to use the powerful molecular genetics available in model organisms to understand fundamental signaling processes underlying normal development, and the abnormalities in these pathways that can lead to cancer. The goal is to provide key new targets for chemopreventive and chemotherapeutic interventions. Program Membership: Since the last renewal, the Developmental Biology Program has undergone several leadership changes. Dr. Bryant stepped down as the program leader to focus on rejuvenating the Graduate Program in Molecular Biology Genetics and Biochemistry and was replaced by Dr. Blumberg. After his stint as Graduate director ended, Dr. Bryant rejoined the program as Co-Leader in 2006 and was replaced by Dr. Marsh in 2007. Drs. Bode and Fallon retired and Dr. Brachmann transitioned to Associate Member. New Members include Dr. Maike Sander who moved from GF, and Drs. Peter Donovan, Taosheng Huang, Tom Schilling, and Rahul Warrior who joined the Program. The DB Program has 16 Members, representing five Departments and two Schools, and has $5,019,083 in direct cancer-related peer-reviewed funding, 1 project of which is funded by NCI for a direct total of $152,000. In 2007, Members published a total of 28 publications with 18 of those being cancer-related of which 22% were inter- and 6% were intra-related.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-16
Application #
8215281
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
16
Fiscal Year
2011
Total Cost
$12,546
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Yu, James; Landberg, Jenny; Shavarebi, Farbod et al. (2018) Bioengineering triacetic acid lactone production in Yarrowia lipolytica for pogostone synthesis. Biotechnol Bioeng 115:2383-2388
Oliver, Andrew; Kay, Matthew; Cooper, Kerry K (2018) Comparative genomics of cocci-shaped Sporosarcina strains with diverse spatial isolation. BMC Genomics 19:310
Mahlbacher, Grace; Curtis, Louis T; Lowengrub, John et al. (2018) Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment. J Immunother Cancer 6:10
Neek, Medea; Tucker, Jo Anne; Kim, Tae Il et al. (2018) Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. Biomaterials 156:194-203
McLelland, Bryce T; Lin, Bin; Mathur, Anuradha et al. (2018) Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci 59:2586-2603
Bota, Daniela A; Chung, Jinah; Dandekar, Manisha et al. (2018) Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol 7:CNS22
Han, Han; Qi, Ruxi; Zhou, Jeff Jiajing et al. (2018) Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell 72:328-340.e8
Solares, Edwin A; Chakraborty, Mahul; Miller, Danny E et al. (2018) Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. G3 (Bethesda) 8:3143-3154
Wang, Yajun; Ngor, Arlene K; Nikoomanzar, Ali et al. (2018) Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun 9:5067
Qiu, Xiaolong; Lombardo, Jeremy A; Westerhof, Trisha M et al. (2018) Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip 18:2776-2786

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