- Optical Biology Core (OBC) The Optical Biology Core consists of a self-use facility (in McGaugh Hall) and a collaboration-based methods development facility located in the Beckman Laser Institute and Medical Clinic (BLIMC) namely, the Laser Microbeam and Medical Program facility (LAMMP), a NIBIB Biomedical Technology Resource Center. The self-use facility contains a Zeiss LSM 780 and a LSM 700 that can image living or fixed material. A two photon laser for deep tissue imaging and single photon lasers for imaging all fluorophores from DAPI (405nm) to far red (633nm) are available on the 780. A FLIM (Fluorescence Lifetime Microscopy) detector for studying molecules based on their fluorescence lifetime provides a way of studying any situation that would typically employ FRET. Dr. Syed manages this facility and provides training and on-site trouble shooting as well as experimental advice. Training is also provided for the Volocity image analysis software package that is available on a high end work station or from individual office computers. The web link is http://obc.bio.uci.edu. The second arm of the OBC includes the LAMMP facility. This NIBIB Biomedical Technology Resource Center is available for collaborative use and protocol development using a number of microscopes and technologies being developed by that center. Information about the capabilities can be found at http://lammp.bli.uci.edu/. These include Multi Dimensional Microscopy (MDM) platforms for studying skin carcinomas, techniques to detect early melanoma non-invasively, and breast cancer screening using visible light (diffuse optical spectroscopy and imaging, DOSI) rather than X-rays. Dr. Krasieva manages this facility and is available for consultation and protocol development for investigators seeking new imaging applications. They are supported by shop facilities that allow construction and modification of imaging platforms.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
United States
Zip Code
Wang, Yajun; Ngor, Arlene K; Nikoomanzar, Ali et al. (2018) Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun 9:5067
Qiu, Xiaolong; Lombardo, Jeremy A; Westerhof, Trisha M et al. (2018) Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip 18:2776-2786
Patterson, Kurt; Yu, James; Landberg, Jenny et al. (2018) Functional genomics for the oleaginous yeast Yarrowia lipolytica. Metab Eng 48:184-196
Lee, J Scott; Roberts, Andrew; Juarez, Dennis et al. (2018) Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med 10:
Sierra, Robert A; Hoverter, Nathan P; Ramirez, Ricardo N et al. (2018) TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development 145:
Maciejewski, Sonia; Ullmer, Wendy; Semler, Bert L (2018) VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology 516:139-146
Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99
Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433
Flather, Dylan; Nguyen, Joseph H C; Semler, Bert L et al. (2018) Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog 14:e1007277
Wang, Xiaolin; Zhao, Da; Phan, Duc T T et al. (2018) A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip 18:2167-2177

Showing the most recent 10 out of 1106 publications