- Chemical & Structural Biology (CSB) The Chemical and Structural Biology (CSB) Program of the Chao Family Comprehensive Cancer Center (CFCCC) seeks to bring UC Irvine's considerable strengths in synthetic chemistry, structural biology, analytical chemistry and related areas to bear on anti-cancer research. These science areas tend to be pursued as single laboratory efforts. Thus, a major thrust of the CSB program is building collaborations and bridges between CSB researchers and cancer biologists and clinicians. In addition to the traditional methods of developing collaborations (e.g., topical retreats and symposia), the CSB leadership runs a very successful molecular matchmaking service, bringing together synthetic chemists, structural biologists and biologists with interesting small molecules. Notable successes of the matchmaking service include a new class of anti-nutrient transporter compounds with exciting anti-cancer activities in vitro and in animal models. Through its activities, the CFCCC directly contributes to the success of the anti-cancer research pursued by CSB members. For example, neuronal nitric oxide synthase emerged as a target for melanoma, and connections forged by the CFCCC led quickly to experiments with highly specific nNOS inhibitors. Similarly, success in the area of analytical chemistry connecting biological recognition with electronics led to connections with prostate and bladder cancer physicians to guide experiments leading to a clinical trial. The CFCCC also provides pilot project funding, which help initiate studies between a synthetic chemist and biologist leading to new types of anti-breast cancer compounds. The CSB leadership also helps to expand the research of its members into cancer-related areas; for example, researchers with a promising new experimental technique for mapping protein-protein interactions with proteomics MS were introduced to different potential collaborators opening new doors and avenues of research. Thus, the CSB program leverages existing efforts and strengths to amplify the quantity and quality of anti-cancer research taking place at UC Irvine. Membership: 22 Members from 8 Departments Funding: $459,979 NCI (Totals); $4,141,394 Other Peer-Reviewed (Totals) Publications: 158 Publications, 16% Inter-programmatic; 6% Intra-programmatic

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-23
Application #
9851367
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
23
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617
Flather, Dylan; Nguyen, Joseph H C; Semler, Bert L et al. (2018) Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog 14:e1007277
Wang, Xiaolin; Zhao, Da; Phan, Duc T T et al. (2018) A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip 18:2167-2177
George, Andrée S; Cox, Clayton E; Desai, Prerak et al. (2018) Interactions of Salmonella enterica Serovar Typhimurium and Pectobacterium carotovorum within a Tomato Soft Rot. Appl Environ Microbiol 84:
Hou, Jue; Williams, Joshua; Botvinick, Elliot L et al. (2018) Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State. Cancer Res 78:2503-2512
Lagarrigue, Frederic; Gingras, Alexandre R; Paul, David S et al. (2018) Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv 2:2358-2368
Reidling, Jack C; Relaño-Ginés, Aroa; Holley, Sandra M et al. (2018) Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports 10:58-72
Ullmer, Wendy; Semler, Bert L (2018) Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells. MBio 9:
Santos, Rommel A; Fuertes, Ariel J C; Short, Ginger et al. (2018) DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev 13:22
Wilford, Justin; Osann, Kathryn; Hsieh, Susie et al. (2018) Validation of PROMIS emotional distress short form scales for cervical cancer. Gynecol Oncol 151:111-116
Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894

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