The Biostatistics Shared Resource provides assistance with statistical aspects of experimental designs, sample size estimation and study power analysis, data acquisition and database development, statistical analysis and interpretation of findings, collaboration on presentation of results, and development of new statistical procedures as required by specific projects. Newly strengthened by a Vanderbilt University School of Medicine Department of Biostatistics, a quadrupling of hardware and software resources available, and tremendous growth in number of investigators served, the Biostatistics Shared Resource has become extraordinarily useful to VICC members in their research. The highlights of the new services of the Biostatistics Shared Resource are design and data analysis for microarray gene expression and proteomic mass spectra experiments. Several faculty biostatisticians devote significant effort to provide expertise in these rapidly developing fields. I addition, the field of statistical genetics has been strengthened by hiring an expert in linkage analysis. Dr. Yu Shyr is responsible for the daily operations of the Biostatistics Shared Resource. As an active member of the monthly Design and Analysis Workshops, he reviews all proposed clinical research protocols and research grant proposals for statistical considerations. This Shared Resource has entered into a cluster arrangement with the Tissue/ Clinical Informatics Shared Resource and the Bioinformatics and Supercomputing Shared Resource, since the three interact so closely and use similar approaches and instruments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-11
Application #
7289858
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
11
Fiscal Year
2006
Total Cost
$243,438
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Burns, Michael C; Howes, Jennifer E; Sun, Qi et al. (2018) High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal Biochem 548:44-52
Phelps, Hannah M; Al-Jadiry, Mazin F; Corbitt, Natasha M et al. (2018) Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq. World J Pediatr 14:585-593
Liu, Qi; Herring, Charles A; Sheng, Quanhu et al. (2018) Quantitative assessment of cell population diversity in single-cell landscapes. PLoS Biol 16:e2006687
Almodovar, Karinna; Iams, Wade T; Meador, Catherine B et al. (2018) Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol 13:112-123
Greenplate, Allison; Wang, Kai; Tripathi, Rati M et al. (2018) Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies. JCO Precis Oncol 2018:
Mi, Deborah J; Dixit, Shilpy; Warner, Timothy A et al. (2018) Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging 71:241-254
Diggins, Kirsten E; Gandelman, Jocelyn S; Roe, Caroline E et al. (2018) Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM). Curr Protoc Cytom 83:10.21.1-10.21.28
Warner, Jeremy L; Prasad, Ishaan; Bennett, Makiah et al. (2018) SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine. JCO Precis Oncol 2018:
Brown, Judy J; Short, Sarah P; Stencel-Baerenwald, Jennifer et al. (2018) Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J Virol 92:
Iams, Wade T; Yu, Hui; Shyr, Yu et al. (2018) First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance. Clin Lung Cancer 19:531-543

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