The Biostatistics Shared Resource provides assistance with statistical aspects of experimental designs, sample size estimation and study power analysis, data acquisition and database development, statistical analysis and interpretation of findings, collaboration on presentation of results, and development of new statistical procedures as required by specific projects. Newly strengthened by a Vanderbilt University School of Medicine Department of Biostatistics, a quadrupling of hardware and software resources available, and tremendous growth in number of investigators served, the Biostatistics Shared Resource has become extraordinarily useful to VICC members in their research. The highlights of the new services of the Biostatistics Shared Resource are design and data analysis for microarray gene expression and proteomic mass spectra experiments. Several faculty biostatisticians devote significant effort to provide expertise in these rapidly developing fields. I addition, the field of statistical genetics has been strengthened by hiring an expert in linkage analysis. Dr. Yu Shyr is responsible for the daily operations of the Biostatistics Shared Resource. As an active member of the monthly Design and Analysis Workshops, he reviews all proposed clinical research protocols and research grant proposals for statistical considerations. This Shared Resource has entered into a cluster arrangement with the Tissue/ Clinical Informatics Shared Resource and the Bioinformatics and Supercomputing Shared Resource, since the three interact so closely and use similar approaches and instruments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-13
Application #
7679676
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
13
Fiscal Year
2008
Total Cost
$692,696
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Iams, Wade T; Yu, Hui; Shyr, Yu et al. (2018) First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance. Clin Lung Cancer 19:531-543
Diggins, Kirsten E; Gandelman, Jocelyn S; Roe, Caroline E et al. (2018) Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM). Curr Protoc Cytom 83:10.21.1-10.21.28
Warner, Jeremy L; Prasad, Ishaan; Bennett, Makiah et al. (2018) SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine. JCO Precis Oncol 2018:
Brown, Judy J; Short, Sarah P; Stencel-Baerenwald, Jennifer et al. (2018) Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J Virol 92:
Engevik, Amy C; Kaji, Izumi; Engevik, Melinda A et al. (2018) Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology 155:1883-1897.e10
Earl, David C; Ferrell Jr, P Brent; Leelatian, Nalin et al. (2018) Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Nat Commun 9:39
Hormuth 2nd, David A; Eldridge, Stephanie L; Weis, Jared A et al. (2018) Mechanically Coupled Reaction-Diffusion Model to Predict Glioma Growth: Methodological Details. Methods Mol Biol 1711:225-241
Lockhart, Jacob N; Spoonmore, Thomas J; McCurdy, Michael W et al. (2018) Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth. ACS Appl Mater Interfaces 10:4050-4056
Rogers, Meredith C; Lamens, Kristina D; Shafagati, Nazly et al. (2018) CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol 201:1253-1266
Takata, Yumie; Xiang, Yong-Bing; Burk, Raymond F et al. (2018) Plasma selenoprotein P concentration and lung cancer risk: results from a case-control study nested within the Shanghai Men's Health Study. Carcinogenesis 39:1352-1358

Showing the most recent 10 out of 2462 publications