The Biostatistics Shared Resource provides professional expertise in biostatistics for Vanderbilt-lngram Cancer Center projects, investigators, and participants. At the time of the last competitive renewal, this shared resource received an """"""""Outstanding"""""""" rating. The Biostatistics Shared Resource director and biostatisticians are constantly available to investigators, and are in regular contact with the leaders of VICC research programs and other shared resources. Functions provided by this shared resource include: 1. To provide study design, power analysis, and sample size estimation services, as well as to review all laboratory, animal, clinical, and prevention studies, including a feasibility assessment, for all VICC investigators; 2. To collaborate in funded research efforts initiated by VICC investigators, providing statistical data analysis, interpretation of results, and the writing of final study reports and manuscripts; 3. To develop and evaluate statistical methods and software for experimental design and data analysis; 4. To provide relational database design, data entry, data tracking, forms, queries, and reports, and to maintain computer databases for information storage and retrieval for investigator-initiated clinical trials or laboratory studies; 5. To work with the Clinical Trials Shared Resource and Cancer Informatics Shared Resource in the development of research project databases, to maintain data quality control and ensure timely data capture;and 6. To train VICC members in research design and data analysis through seminars, short statistical workshops, or individual sessions on statistical methods. Biostatistics Shared Resource personnel have worked and will continue to work closely with VICC investigators to assure that the Biostatistics Shared Resource provides state-of-the-art statistical support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA068485-14
Application #
8180603
Study Section
Subcommittee G - Education (NCI)
Project Start
2010-09-10
Project End
2015-08-31
Budget Start
2010-09-10
Budget End
2011-08-31
Support Year
14
Fiscal Year
2010
Total Cost
$297,713
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Gilchuk, Pavlo; Kuzmina, Natalia; Ilinykh, Philipp A et al. (2018) Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity 49:363-374.e10
Hebron, Katie E; Li, Elizabeth Y; Arnold Egloff, Shanna A et al. (2018) Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep 8:3208
Bangaru, Sandhya; Zhang, Heng; Gilchuk, Iuliia M et al. (2018) A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun 9:2669
Means, Anna L; Freeman, Tanner J; Zhu, Jing et al. (2018) Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6:257-276
Du, Zhenfang; Lovly, Christine M (2018) Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer 17:58
Zhang, Qin; Jeppesen, Dennis K; Higginbotham, James N et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol 5:627-629.e6
Elion, David L; Cook, Rebecca S (2018) Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment. Oncotarget 9:29007-29017
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255

Showing the most recent 10 out of 2462 publications