PROJECT 003 ? SIGNAL TRANSDUCTION AND CHEMICAL BIOLOGY PROJECT SUMMARY/ABSTRACT The Signal Transduction and Chemical Biology Research Program (ST) is an active group of basic scientists focused on signaling networks that control cell proliferation, stem cell function and tumorigenesis, and the development of chemical inhibitors for these signaling pathways. The Program has changed the name from Signal Transduction and Cell Proliferation since the last renewal to reflect that inhibitors of mutant or activated signaling components have had a major impact in genotype-driven clinical trials and that future therapeutic advances will require a better understanding of signaling networks and how these networks change and evolve during cancer progression and in response to inhibitors (e.g., mechanisms of resistance). ST goals are to understand how perturbations in signaling networks drive the development of cancer, to use this information to identify therapeutic targets, and to develop new chemical tools or even lead compounds for new therapeutics. This Program seeks to leverage the genetic analysis of cancer (e.g., TCGA data and/or the CE Program), stem cell biology and high-content systems analysis of signaling networks for the identification of key nodes that can be tested in model systems (e.g., using new technology such as CRISPR/Cas9), used for the synthesis of inhibitors, and that eventually can be targeted therapeutically. ST is organized into several groups with common interests: signaling networks, chemical biology, stem cell biology and cell cycle control. The overall goals are to promote outstanding basic research in signaling networks and to provide intellectual support for clinical programs working with inhibitors of signaling and cell cycle pathways; to stimulate interactions among the Program membership to accelerate discovery; to stimulate the use of new technologies; and to work closely with Vanderbilt-Ingram Cancer Center (VICC) shared resources to make new instrumentation and methods available that will accelerate cancer research. There are 41 program members from 13 departments and three schools, with $3.9M in NCI funding and $6.3M in other peer-reviewed cancer-related funding. Out of 458 publications, 12% are intra-programmatic and 28% are inter-programmatic. Members also have 143 collaborative publications with investigators at other institutions.

Public Health Relevance

PROJECT 003 ? SIGNAL TRANSDUCTION AND CHEMICAL BIOLOGY PROJECT NARRATIVE Per the PAR-13-386 FOA, the project narrative is not applicable for the Signal Transduction and Chemical Biology Research Program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
6P30CA068485-20
Application #
9248564
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2016-04-30
Budget End
2016-08-31
Support Year
20
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Cardin, Dana B; Thota, Ramya; Goff, Laura W et al. (2018) A Phase II Study of Ganetespib as Second-line or Third-line Therapy for Metastatic Pancreatic Cancer. Am J Clin Oncol 41:772-776
Bloodworth, Melissa H; Rusznak, Mark; Pfister, Connor C et al. (2018) Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology. J Allergy Clin Immunol 142:683-687.e12
Saito-Diaz, Kenyi; Benchabane, Hassina; Tiwari, Ajit et al. (2018) APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell 44:566-581.e8
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Hormuth 2nd, David A; Weis, Jared A; Barnes, Stephanie L et al. (2018) Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer. Int J Radiat Oncol Biol Phys 100:1270-1279
Rojas, Juan D; Lin, Fanglue; Chiang, Yun-Chen et al. (2018) Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy. Theranostics 8:141-155
Lewis Jr, James S; Shelton, Jeremy; Kuhs, Krystle Lang et al. (2018) p16 Immunohistochemistry in Oropharyngeal Squamous Cell Carcinoma Using the E6H4 Antibody Clone: A Technical Method Study for Optimal Dilution. Head Neck Pathol 12:440-447
Vierra, Nicholas C; Dickerson, Matthew T; Jordan, Kelli L et al. (2018) TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab 9:84-97
Schlegel, Cameron; Weis, Victoria G; Knowles, Byron C et al. (2018) Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci 63:356-365
Piñeros, Marion; Frech, Silvina; Frazier, Lindsay et al. (2018) Advancing Reliable Data for Cancer Control in the Central America Four Region. J Glob Oncol :1-11

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