TRANSLATIONAL RESEARCH GROUP CORE 008 ? ANIMAL AND HUMAN IMAGING SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Animal and Human Imaging Shared Resource (AHISR) has been supported by the Cancer Center Support Grant (CCSG) since 2004. The AHISR provides scientific and technical assistance for experiments employing biomedical imaging to study cancer in both the preclinical and clinical settings, and will undertake developments to meet the needs of the Vanderbilt-Ingram Cancer Center (VICC). The faculty and staff within the AHISR provide access to state-of-the-art imaging facilities including advanced human MRI systems operating at 3T and 7T as well as a comprehensive facility for animal imaging and research radiopharmaceuticals for animal and human use. Furthermore, the AHISR leverages the resources in the VICC with the Vanderbilt University Institute of Imaging Science (VUIIS) to develop new and improved methods for obtaining information that addresses research questions of direct cancer relevance. More specifically, the AHISR provides: 1. Collaborations with expert imaging science faculty (in nuclear, optical, magnetic resonance and ultrasound imaging) for the development and application of cutting-edge imaging protocols 2. Innovative and novel radiopharmaceuticals for animal and human imaging research 3. Support for imaging system operators and technical staff who will handle patient and animal preparation and monitoring as well as operate the instruments 4. Support for data analysis and for quantitative image analysis customized to specific applications, including the co-registration and integration of multiple modalities, histology and proteomics The AHISR brings together expensive equipment and diverse expertise into a comprehensive integrated resource. Supporting a professional staff dedicated to cancer imaging through the AHISR will ensure that the quality of the imaging data, and consequently, the overall quality of studies, is the highest possible.

Public Health Relevance

TRANSLATIONAL RESEARCH GROUP CORE 008 ? ANIMAL AND HUMAN IMAGING SHARED RESOURCE PROJECT NARRATIVE Per the PAR-13-386 FOA, the project narrative is not applicable for the Animal and Human Imaging Shared Resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-21
Application #
9152302
Study Section
Subcommittee A - Cancer Centers (NCI-A)
Program Officer
Marino, Michael A
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
21
Fiscal Year
2016
Total Cost
$191,098
Indirect Cost
$69,380
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Hebron, Katie E; Li, Elizabeth Y; Arnold Egloff, Shanna A et al. (2018) Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep 8:3208
Bangaru, Sandhya; Zhang, Heng; Gilchuk, Iuliia M et al. (2018) A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun 9:2669
Gilchuk, Pavlo; Kuzmina, Natalia; Ilinykh, Philipp A et al. (2018) Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity 49:363-374.e10
Du, Zhenfang; Lovly, Christine M (2018) Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer 17:58
Zhang, Qin; Jeppesen, Dennis K; Higginbotham, James N et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol 5:627-629.e6
Means, Anna L; Freeman, Tanner J; Zhu, Jing et al. (2018) Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6:257-276
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Elion, David L; Cook, Rebecca S (2018) Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment. Oncotarget 9:29007-29017
Yang, Yaohua; Cai, Qiuyin; Shu, Xiao-Ou et al. (2018) Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer :

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