The Cancer Pathology Facility has two primary goals. The first goal is to provide high quality, well documented samples of human tissues to investigators of the Oregon Cancer Center for use in molecular and immunohistochemical studies. The samples will be obtained from surgical re-section specimens and autopsies at hospitals affiliated with the Cancer Center, and will consist of frozen tissue, paraffin-embedded tissue, or purified DNA. The nature and quality of all collected tissues will be evaluated by the Core Director (a practicing surgical pathologist) prior to delivery to interested research. Related clincopathologic data will also be made available to researchers in a manner that guarantees patient confidentiality. The second goal of the Core Facility is to provide to Cancer Center investigators a full range of histology services for the study of human tissues and tissues from research animals. These services will include paraffin-embedding and sectioning, cryostat sectioning, histochemical staining, immunostaining, and in-situ hybridization. In addition, tissue microdissection with a laser capture microscope will be performed on request. Through these services, the Core Facility will serve as an important resource for basic and translational research activities in the Oregon Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA069533-04
Application #
6401788
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
1997-08-01
Project End
2005-05-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Hulett, Tyler W; Jensen, Shawn M; Wilmarth, Phillip A et al. (2018) Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination. J Immunother Cancer 6:27
Vranka, Janice A; Staverosky, Julia A; Reddy, Ashok P et al. (2018) Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures. Invest Ophthalmol Vis Sci 59:246-259
Lane, Ryan S; Lund, Amanda W (2018) Non-hematopoietic Control of Peripheral Tissue T Cell Responses: Implications for Solid Tumors. Front Immunol 9:2662
Tyner, Jeffrey W; Tognon, Cristina E; Bottomly, Daniel et al. (2018) Functional genomic landscape of acute myeloid leukaemia. Nature 562:526-531
Risom, Tyler; Langer, Ellen M; Chapman, Margaret P et al. (2018) Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer. Nat Commun 9:3815
Minnier, Jessica; Pennock, Nathan D; Guo, Qiuchen et al. (2018) RNA-Seq and Expression Arrays: Selection Guidelines for Genome-Wide Expression Profiling. Methods Mol Biol 1783:7-33
Su, Yulong; Pelz, Carl; Huang, Tao et al. (2018) Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals. Genes Dev 32:1398-1419
Gast, Charles E; Silk, Alain D; Zarour, Luai et al. (2018) Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival. Sci Adv 4:eaat7828
Krey, Jocelyn F; Scheffer, Deborah I; Choi, Dongseok et al. (2018) Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells. Sci Data 5:180128
Rozanov, Dmitri V; Rozanov, Nikita D; Chiotti, Kami E et al. (2018) MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection. J Proteomics 176:13-23

Showing the most recent 10 out of 277 publications