Preventing the initiation of tobacco or nicotine products is critical to comprehensive tobacco and cancer control. This Revision Application Relevant to the Family Smoking Prevention and Tobacco Control Act provides the opportunity to conduct novel research that increases our understanding on how to prevent tobacco and nicotine use among the most vulnerable populations: youths, young adults, and racial/ethnic groups at high risk for tobacco-caused cancers. The three proposed projects identify how consumer perceptions, product design characteristics, and/or individual traits influence willingness to smoke and susceptibility to menthol cigarette or e-cigarette use. Project 1 examines the perceptions of the sensory characteristics of menthol cigarettes and the contributions of taste sensitivity to susceptibility to menthol cigarette use among never smokers, experimenters, and new smokers aged 18-26. Studies show that menthol increases the likelihood of experimentation, but have not assessed how menthol influences smoking initiation among racial/ethnic groups at high risk for menthol cigarette smoking and lung cancer. This study can provide evidence to the FDA on the potential harm of menthol in cigarettes to vulnerable groups. Project 2 employs an experimental design to examine how e-cigarette advertisements influence implicit and explicit attitudes toward e-cigarettes as healthier alternatives to cigarettes and how the advertisements are associated with susceptibility to e-cigarette use among current smokers aged 18-35. Little is known about the influence of e-cigarette marketing on public perceptions of e-cigarettes. This study can provide the FDA with new knowledge that will inform future e-cigarette regulations and facilitate marketing restrictions on misleading health claims. Project 3 employs an experimental design to investigate how colors, models, and health labeling influence adolescent (aged 12-14) reactions to cigarette advertising and examine gender and racial/ethnic differences in implicit and explicit measures, smoking expectancies, identification with smokers, and willingness to smoke. Studies show that tobacco industry advertising and packaging influence smoking initiation, but little is known about the mechanisms by which they influence initiation. This study can inform the FDA's regulation of specific advertising components that influence positive reactions to advertising.

Public Health Relevance

Preventing the initiation of menthol cigarettes, regular cigarettes, and e-cigarettes could substantially reduce tobacco-related morbidity and mortality rates in the U.S. The studies will collectively advance our knowledge on how consumer perceptions of products, product design characteristics, and individual traits influence adolescents'and young adults'risk for the initiation of products. Study results could potentially impact FDA's decision to use its authority to adopt new policy-based prevention strategies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA071789-14S4
Application #
8641479
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shafik, Hasnaa
Project Start
1997-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Type
Organized Research Units
DUNS #
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Shimizu, Yoshiko; Furuya, Hideki; Tamashiro, Paulette M et al. (2018) Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model. Carcinogenesis 39:47-55
Aumueller, Nicole; Boushey, Carol J; Franke, Adrian A et al. (2018) Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC). Eur J Clin Nutr :
Huang, Brian Z; Le Marchand, Loic; Haiman, Christopher A et al. (2018) Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study. Int J Cancer 142:2019-2027
Jenkins, Mark A; Win, Aung Ko; Templeton, Allyson S et al. (2018) Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC). Int J Epidemiol 47:387-388i
Naderi, Ali (2018) SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies. Mol Oncol 12:724-755
Franke, Adrian A; Li, Xingnan; Menden, Ariane et al. (2018) Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry. Drug Test Anal :
Fanidi, Anouar; Muller, David C; Yuan, Jian-Min et al. (2018) Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3). J Natl Cancer Inst 110:
Rohrmann, Sabine; Shvetsov, Yurii B; Morimoto, Yukiko et al. (2018) Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort. Cancer Causes Control 29:601-607
Faouzi, Malika; Neupane, Ram P; Yang, Jian et al. (2018) Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells. Sci Rep 8:1075
Nishioka, Scott T; Sato, Miles M; Wong, Linda L et al. (2018) Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort. Hepatoma Res 4:

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