Rapid developments in cell biology, molecular biology, and genetics produced an increased demand for human tissues to study the relevance of laboratory discoveries to human disease. Despite this increasing need, the amount of tissue samples available for research continues to decline due, in part, to an improved ability to detect cancers of smaller size, a smaller amount of tissue needed for diagnosis, and stringent rules of acquisition of tissue. Early in the development of CINJ the members expressed a strong cross-programmatic interest in a central source for obtaining human tissues and other biological materials. CINJ organized the institution's first centralized mechanism to collect and distribute tissues to clinical and laboratory scientists. Since the formal start of the Tissue Retrieval Service, 6,000 samples have been collected on behalf of members of all seven CINJ research programs. The overall purpose of the Tissue Retrieval Service Shared Resource is to provide human tissue samples and biological materials to the membership of CINJ. The specific objectives of this shared resource are as follows: 1. To procure, prepare, and distribute normal, benign, and malignant human tissues in the requested quantities and state of preservation for use by CINJ investigators. 2. To provide clinical, pathological, and outcome information through a confidential database, so that findings from basic research can be correlated with clinical data while maintaining strict patient confidentiality. 3. To provide consultation to CINJ investigators in the design of clinical research protocols that require tissue procurement for scientific correlations. 4. To ensure proper Institutional Review Board approval for the use of human tissues for research purposes, and to ensure that standard safety guidelines are followed by personnel using these materials. 5. To facilitate completion of investigator-initiated clinical trials by collection of tissues and blood products according to specific protocols through coordination with the CINJ Clinical Research Office. The Tissue Retrieval Service is directed by Drs. David August and Karel Raska, Jr. The Tissue Retrieval Shared Resource was used by 22 CINJ members in 1998. These members participate in all seven CINJ programs and represent ten academic departments. CINJ members account for 93% of all usage of this shared resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA072720-05
Application #
6434920
Study Section
Project Start
2001-03-09
Project End
2002-02-28
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Farber, Nicholas J; Radadia, Kushan D; Singer, Eric A (2018) Accuracy of Nodal Staging and Outcomes of Lymphadenectomy for Non-metastatic Renal Cell Carcinoma: An Analysis of the National Cancer Database. Bladder Cancer 4:S14-S15
Poillet-Perez, Laura; Xie, Xiaoqi; Zhan, Le et al. (2018) Autophagy maintains tumour growth through circulating arginine. Nature 563:569-573
Chan, Chang S; Laddha, Saurabh V; Lewis, Peter W et al. (2018) ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nat Commun 9:4158
Panda, Anshuman; de Cubas, Aguirre A; Stein, Mark et al. (2018) Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma. JCI Insight 3:
Warner, Wayne A; Lee, Tammy Y; Fang, Fang et al. (2018) The burden of prostate cancer in Trinidad and Tobago: one of the highest mortality rates in the world. Cancer Causes Control 29:685-697
Zhao, Yuhan; Wu, Lihua; Yue, Xuetian et al. (2018) A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. Elife 7:
Deek, Matthew P; Kim, Sinae; Ahmed, Inaya et al. (2018) Prognostic Impact of Missed Chemotherapy Doses During Chemoradiation Therapy for Non-Small Cell Lung Cancer. Am J Clin Oncol 41:362-366
O'Malley, Denalee; Dewan, Asa A; Ohman-Strickland, Pamela A et al. (2018) Determinants of patient activation in a community sample of breast and prostate cancer survivors. Psychooncology 27:132-140
Park, Kihan; Chen, Wenjin; Chekmareva, Marina A et al. (2018) Electromechanical Coupling Factor of Breast Tissue as a Biomarker for Breast Cancer. IEEE Trans Biomed Eng 65:96-103
Jang, Thomas L; Patel, Neal; Faiena, Izak et al. (2018) Comparative effectiveness of radical prostatectomy with adjuvant radiotherapy versus radiotherapy plus androgen deprivation therapy for men with advanced prostate cancer. Cancer 124:4010-4022

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