The tobacco industry is relying on product and marketing innovation to drive future growth. The electronic or e- cigarette market provides a much needed area of growth for tobacco manufacturers, including the major cigarette manufacturers. The cigar market is another potential area for growth given the extensive variety of products available. E-cigarettes and cigars are not currently subject to the same FDA regulations as cigarettes and as result, the flavorings, product descriptors;and packaging in these markets vary more widely. In addition, the marketing strategies for e-cigarettes appear to highlight their potential for harm reduction. Such marketing will likely stimulate demand as well as questions to providers from patients about the safety of-cigarettes. Marketing of e-cigarettes has also become more mainstream as more brands are nationally advertised. Brand as well as flavor and packaging are also particularly important to cigar users. This revision application describes a plan to conduct three individual research projects that provide scientific data that can inform FDA regulation of e-cigarettes and cigars. These three projects respond to four of the FDA Center for Tobacco Products'research interest areas identified in the FOA including areas 2 (cigar use and perceptions), 4 (e-cigarette use and perceptions), 6 (impact of tobacco product characteristics on initiation) and 10 (effective communication strategies regarding the risk of tobacco products). Specifically, we plan to examine patient-provider communication related to e-cigarettes, explore the influence of ecigarette marketing on consumer perceptions and product trial, and investigate the impact of cigar product characteristics on young adults'cigar use and perceptions. Quantitative and qualitative data will be collected on the multiple factors that potentially influence the use of these products. Thus, the significance of this proposed research is its potential to generate a better understanding of e-cigarette and cigar use and perceptions which is vital to informing FDA tobacco product regulation.

Public Health Relevance

The purpose of this application seeks to better understand and address the factors that impact perceptions and use of e-cigarettes and cigars. The relevance of the proposed research to public health is its ability to advance the evidence base to inform FDA tobacco product regulation.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Marino, Michael A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Rbhs -Cancer Institute of New Jersey
New Brunswick
United States
Zip Code
Severson, Eric A; Riedlinger, Gregory M; Connelly, Caitlin F et al. (2018) Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens. Blood 131:2501-2505
Shih, Weichung Joe; Lin, Yong (2018) Relative efficiency of precision medicine designs for clinical trials with predictive biomarkers. Stat Med 37:687-709
Ding, Qiang; Gaska, Jenna M; Douam, Florian et al. (2018) Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A 115:E6310-E6318
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Modi, Parth K; Wang, Ye; Kirk, Peter S et al. (2018) The Receipt of Industry Payments is Associated With Prescribing Promoted Alpha-blockers and Overactive Bladder Medications. Urology 117:50-56
Dai, Zhuqing; Feng, Simin; Liu, Anna et al. (2018) Anti-inflammatory effects of newly synthesized ?-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice. Food Res Int 109:350-357
Lee, Jongin; Lee, Daehwan; Sim, Mikang et al. (2018) mySyntenyPortal: an application package to construct websites for synteny block analysis. BMC Bioinformatics 19:216
Farber, Nicholas J; Faiena, Izak; Dombrovskiy, Viktor et al. (2018) Disparities in the Use of Continent Urinary Diversions after Radical Cystectomy for Bladder Cancer. Bladder Cancer 4:113-120
Feng, Simin; Dai, Zhuqing; Liu, Anna B et al. (2018) Intake of stigmasterol and ?-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet. Biochim Biophys Acta Mol Cell Biol Lipids 1863:1274-1284
DeRenzo, Evan G; Moss, Joel; Singer, Eric A (2018) Implications of the Revised Common Rule for Human Participant Research. Chest :

Showing the most recent 10 out of 775 publications