8.1.1 ABSTRACT: PREVENTION AND ETIOLOGY The Prevention &Etiology program, lead by Dorothy Hatsukami, Ph.D: and DeAnn Lazovich, Ph.D., has 51 members, representing 12 departments and six schools or colleges (Medical?Twin Cities and Duluth, Public Health, Food, Agricultural and Natural Resources, Pharmacy, Nursing, Social Work). As of October 1, 2007, these members have a total of $28 million in Peer-reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 667 publications, of which 27% were intraprogrammatic and 10% were inter-programmatic. The scientific goals of this program are to understand biological and behavioral factors in the etiology of cancer, reduce behaviors that may lead to cancer or enhance behaviors that decrease cancer risk, and improve the survivorship of cancer patients. To achieve these goals, we have strong research programs that fall into three primary themes: 1) cancer risk reduction, which examines environmental, behavioral and biological factors associated with etiology and the reduction of tobacco, obesity and physical inactivity;2) adult and pediatric cancer epidemiology, which explores molecular genetic, physiological, nutritional and environmental influences that increase or decrease the risk for cancers;and 3) cancer diagnosis, outcomes and survivorship, which explores the efficacy of cancer screening to reduce cancer mortality arid the consequences of cancer treatments and methods to improve cancer outcomes and quality of life. The Cancer Center has provided not only shared resources, but has funded 32 pilot projects, two research retreats, three monthly seminar meetings on tobacco, epidemiology, and cancer survivorship and outcomes, and a Prevention and Etiology newsletter to facilitate collaborations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-14
Application #
8374844
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
14
Fiscal Year
2012
Total Cost
$29,088
Indirect Cost
$10,173
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Regan Anderson, Tarah M; Ma, Shihong; Perez Kerkvliet, Carlos et al. (2018) Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res 16:1761-1772
Santiago, Victor; Lazaryan, Aleksandr; McClune, Brian et al. (2018) Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome. Leuk Lymphoma 59:958-966
Grzywacz, Bartosz; Moench, Laura; McKenna Jr, David et al. (2018) Natural Killer Cell Homing and Persistence in the Bone Marrow After Adoptive Immunotherapy Correlates With Better Leukemia Control. J Immunother :
Boatman, Jeffrey A; Vock, David M; Koopmeiners, Joseph S et al. (2018) Estimating causal effects from a randomized clinical trial when noncompliance is measured with error. Biostatistics 19:103-118
Guo, Jingshu; Villalta, Peter W; Weight, Christopher J et al. (2018) Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Chem Res Toxicol :
Teitelbaum, A M; Murphy, S E; Akk, G et al. (2018) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J 18:136-143
Rashidi, Armin; Shanley, Ryan; Yohe, Sophia L et al. (2018) Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples. Br J Haematol 182:887-894
Bellamri, Medjda; Xiao, Shun; Murugan, Paari et al. (2018) Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci 163:543-556
Murphy, Sharon E; von Weymarn, Linda B; Parenteau, Marc et al. (2018) Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol 31:168-175
Hegerova, Livia; Bachan, Adam; Cao, Qing et al. (2018) Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation. Biol Blood Marrow Transplant 24:e20-e25

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