The mission of the Translational Therapy Shared Resource (TTSR) is to provide state-of-the-art translational research support services to Masonic Cancer Center (MCC) members to facilitate the monitoring of clinical trials and the development of novel GMP-grade cellular and immune-based therapies. These services are essential to the mission of the MCC because transitioning sophisticated laboratory assays and the manufacturing of biotherapeutic products to the clinic can be difficult and often represents a significant hurdle in translating laboratory studies to patient care. TTSR works directly with members of the scientific programs at the preclinical, clinical, and laboratory levels, with the goal of developing clinical trials to test novel therapies. The TTSR is led by Dr. Martin Felices, PhD, and Dr. John Wagner, MD, with support from Drs. Julie Curtsinger, PhD; David McKenna, MD; and their personnel. It has 2 major components, the Translational Therapy Laboratory (TTL) and Molecular and Cellular Therapeutics (MCT). The TTL provides immune monitoring and biorepository management; it is the central laboratory that receives and processes research blood samples from patients enrolled in clinical trials. MCT is a cGMP-compliant production facility capable of generating GMP-grade cellular and molecular products. The 2 components synergize to help translate promising new therapies into the clinic and to assess biologic outcomes once in patients. The resource has undergone the following changes since the 2013 renewal: ? David McKenna was awarded an NHLBI grant to assist with Production Assistance for Cellular Therapies (PACT). This assists with MCT operational funding. ? Our clinical partner, Fairview, increased its investment in TTSR, highlighting their continued commitment to the Resource. This investment is critical for maintaining TTSR personnel and operations going forward. ? The number of TTL-supported studies has gone up 40% since the last CCSG competing renewal application, resulting in an uptick in the number of clinical samples being processed and managed by this component of the core. ? TTL expanded its biorepository capabilities and now supports a number of solid-tumor studies with processing and storage. ? With the departure of Michael Verneris, Martin Felices assumed the role of Co-Director in 2016. Dr. Felices is an Assistant Professor of Medicine who is well versed in basic and translational immunology and has worked extensively with TTL, first as a researcher and later as part of the core leadership.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-23
Application #
10086444
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1998-06-01
Project End
2024-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
23
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Murphy, Sharon E; von Weymarn, Linda B; Parenteau, Marc et al. (2018) Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol 31:168-175
Bellamri, Medjda; Xiao, Shun; Murugan, Paari et al. (2018) Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci 163:543-556
Jarvis, Matthew C; Ebrahimi, Diako; Temiz, Nuri A et al. (2018) Mutation Signatures Including APOBEC in Cancer Cell Lines. JNCI Cancer Spectr 2:
Hegerova, Livia; Bachan, Adam; Cao, Qing et al. (2018) Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation. Biol Blood Marrow Transplant 24:e20-e25
Lassig, Amy Anne D; Bechtold, Joan E; Lindgren, Bruce R et al. (2018) Tobacco exposure and wound healing in head and neck surgical wounds. Laryngoscope 128:618-625
Petzel, Sue V; Isaksson Vogel, Rachel; Cragg, Julie et al. (2018) Effects of web-based instruction and patient preferences on patient-reported outcomes and learning for women with advanced ovarian cancer: A randomized controlled trial. J Psychosoc Oncol 36:503-519
Pierpont, Elizabeth I; McCoy, Erin; King, Kelly E et al. (2018) Post-transplant adaptive function in childhood cerebral adrenoleukodystrophy. Ann Clin Transl Neurol 5:252-261
Passow, Kellan T; Harki, Daniel A (2018) 4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue. Org Lett 20:4310-4313
Guo, Zhijun; Johnson, Veronica; Barrera, Jaime et al. (2018) Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them. Cancer Metastasis Rev 37:409-423
Scott, Milcah C; Temiz, Nuri A; Sarver, Anne E et al. (2018) Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma. Cancer Res 78:326-337

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