The Cancer Prevention and Control (CPC) Program has evolved to establish strong intra- and inter-programmatic collaborations with all IUSCC Programs (HMI, EDT, TMM, and BCP). The Program's external partnerships with other universities and cancer centers can be traced back to 1995 when Program Leader, Dr. Victoria Champion founded the Behavioral Cooperative Oncology Group (BCOG) a consortium of senior scientists from the University of Michigan, Michigan State, Ohio State, Purdue, and Indiana University whose purpose was to conduct significant and innovative cancer control research and train interdisciplinary future scientists. CPC goals are addressed through three Themes: 1) Prevention, 2) Early Detection, and 3) Survivorship. Each Theme approaches a challenge crucial to decreasing cancer morbidity and mortality. Within Theme 1, CPC researchers study new HPV vaccine delivery methods to enhance global accessibility and work towards decreasing the prevalence of tobacco use through smoking prevention, cessation, and relapse reduction research which is translated into evidence-based interventions for the community. Theme 2 researchers are identifying colorectal cancer (CRC) risk algorithms to aid in selecting appropriate screening tests, and addressing cervical and CRC screening compliance issues. Finally, Theme 3 researchers are evaluating mechanisms and treatment options for prevention of chemotherapy-induced neurotoxicity and cognitive dysfunction, and developing and testing interventions to decrease symptom burden. CPC has 26 full and 11 associate members, representing 13 departments and 9 schools on the campuses of Indiana University School of Medicine (IUSOM), Indiana University-Purdue University Indianapolis (lUPUl) and Notre Dame. The Program has a total of $4.4M in current peer reviewed funding, with $1.8M from the NCI, $1.7M from other NIH branches, $159K in ACS funds, and $744K in other peer-reviewed funding. Over the past funding period, CPC members have authored a total of 311 publications. Of these, 36% represent intra-programmatic collaborations, 14.1% represent inter-programmatic collaborations, and 21.2% represent inter-institutional collaborations.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A et al. (2018) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell 172:191-204.e10
Filley, Anna; Henriquez, Mario; Bhowmik, Tanmoy et al. (2018) Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas. J Neurooncol 137:469-479
Sishtla, Kamakshi; Pitt, Natalie; Shadmand, Mehdi et al. (2018) Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep 8:16152
Koh, Byunghee; Abdul Qayum, Amina; Srivastava, Rajneesh et al. (2018) A conserved enhancer regulates Il9 expression in multiple lineages. Nat Commun 9:4803
Reese, Michael J; Knapp, Deborah W; Anderson, Kimberly M et al. (2018) In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. PLoS One 13:e0203517
Singh, Pratibha; Fukuda, Seiji; Liu, Liqiong et al. (2018) Survivin Is Required for Mouse and Human Bone Marrow Mesenchymal Stromal Cell Function. Stem Cells 36:123-129
Olivos 3rd, David J; Perrien, Daniel S; Hooker, Adam et al. (2018) The proto-oncogene function of Mdm2 in bone. J Cell Biochem 119:8830-8840
Shiue, Kevin; Cerra-Franco, Alberto; Shapiro, Ronald et al. (2018) Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy. J Thorac Oncol 13:1549-1559

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