Acknowledging the critique from the last CCSG competitive renewal, the IUSCC has made the increase of the depth of clinical and translational studies at IUSCC part of its ongoing strategic plan. To achieve this goal, we have leveraged Project Management resources through the IUSCC Translational Research Acceleration Collaboration (ITRAC) to coordinate translational projects and cultivate a more robust translational/clinical research portfolio. The project management initiative under the guidance of the Associate Director (AD) of Clinical Research, Dr. Sherif Farag and the AD of Basic Science Research, Dr. Mark Kelley facilitates collaborations by removing traditional barriers between bench and clinical research, and aids in identifying funding resource options (more information on the ITRAC initiative is in section 7.4 Developmental Funds). The Clinical Research Office (CRO) protocol development service team works closely with the ITRAC Project Management team during study design to promote and assist with interdisciplinary connections/collaborations among investigators. These collaborations often involve the connection of junior clinicians with senior clinical and basic science research leaders for mentoring in the development of competitive internal and extramural grant applications (e.g. NIH ROI, R21, multi-PI ROI, U01 and peer-reviewed foundational funding).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA082709-15
Application #
8781107
Study Section
Subcommittee G - Education (NCI)
Project Start
1999-09-22
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
$70,247
Indirect Cost
$28,339
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A et al. (2018) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell 172:191-204.e10
Filley, Anna; Henriquez, Mario; Bhowmik, Tanmoy et al. (2018) Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas. J Neurooncol 137:469-479
Sishtla, Kamakshi; Pitt, Natalie; Shadmand, Mehdi et al. (2018) Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep 8:16152
Koh, Byunghee; Abdul Qayum, Amina; Srivastava, Rajneesh et al. (2018) A conserved enhancer regulates Il9 expression in multiple lineages. Nat Commun 9:4803
Reese, Michael J; Knapp, Deborah W; Anderson, Kimberly M et al. (2018) In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. PLoS One 13:e0203517
Singh, Pratibha; Fukuda, Seiji; Liu, Liqiong et al. (2018) Survivin Is Required for Mouse and Human Bone Marrow Mesenchymal Stromal Cell Function. Stem Cells 36:123-129
Olivos 3rd, David J; Perrien, Daniel S; Hooker, Adam et al. (2018) The proto-oncogene function of Mdm2 in bone. J Cell Biochem 119:8830-8840
Shiue, Kevin; Cerra-Franco, Alberto; Shapiro, Ronald et al. (2018) Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy. J Thorac Oncol 13:1549-1559

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