Abstract

The Indiana University Simon Cancer Center (IUSCC) Tissue Procurement and Distribution Core (also called the Tissue Core) was set up to bank fresh surgically obtained human tissue. Services have expanded to include sample collections for: fresh, frozen, and formalin fixed paraffin-embedded tissue; whole blood, plasma, serum and cellular (MNC/DNA) components; bone marrow aspirate; and core biopsies. Other services include: H&E staining and slide preparation; tissue microarray preparation; digital scanning using the Aperio Imaging System; purification of for chronic lymphocytic leukemia and multiple myeloma cells from blood and bone marrow by immunomagnetic selection; collection of defined data parameters; and assistance with approved PI initiated sample collections. The Tissue Core currently supports 42 different IRB protocols, and support for PI IRB protocols has steadily increased over the last three years. This shared resource utilizes IU Health University Hospital, IUSCC, Wishard, Riley Hospital for Children, and Methodist Research Institution. Also utilized are other facilities in the catchment area of the State of Indiana: St. Joseph Regional Medical Center & South Bend Clinic; Arnett Clinic in Lafayette; IU Health Pathology and Laboratory Morgue; and the Marion County Morgue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA082709-19S2
Application #
9778733
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
19
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A et al. (2018) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell 172:191-204.e10
Filley, Anna; Henriquez, Mario; Bhowmik, Tanmoy et al. (2018) Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas. J Neurooncol 137:469-479
Sishtla, Kamakshi; Pitt, Natalie; Shadmand, Mehdi et al. (2018) Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep 8:16152
Koh, Byunghee; Abdul Qayum, Amina; Srivastava, Rajneesh et al. (2018) A conserved enhancer regulates Il9 expression in multiple lineages. Nat Commun 9:4803
Reese, Michael J; Knapp, Deborah W; Anderson, Kimberly M et al. (2018) In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. PLoS One 13:e0203517
Singh, Pratibha; Fukuda, Seiji; Liu, Liqiong et al. (2018) Survivin Is Required for Mouse and Human Bone Marrow Mesenchymal Stromal Cell Function. Stem Cells 36:123-129
Olivos 3rd, David J; Perrien, Daniel S; Hooker, Adam et al. (2018) The proto-oncogene function of Mdm2 in bone. J Cell Biochem 119:8830-8840
Shiue, Kevin; Cerra-Franco, Alberto; Shapiro, Ronald et al. (2018) Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy. J Thorac Oncol 13:1549-1559

Showing the most recent 10 out of 256 publications