Bioinformatics is playing an increasingly important role in cancer research extending from basic evaluation of cancer genetics through translational and clinical research. It is also playing an important role in connecting fields of cancer research that were previously thought to be separate, and to assisting other shared resources in sharing and utilizing large volumes of data. The mission of the HCCC Bioinformatics Shared Resource is to support the informatics needs of the clinical, basic and population scientists of the HCCC. This shared resource has the expertise to collect and utilize large-scale data sets, including molecular assays, is available to all HCCC members. Such uses are rarely a simple matter of deploying an existing software tool by the end user, thus the staff of this shared resource will assist investigators throughout the phases of experiment design and collaborate with the investigator and other shared research resources such as the DNA core and Biostatistics Core in data analysis and interpretation. Bioinformatics Shared Resource staff have the expertise to develop software tools de novo or to adapt existing tools to custom settings.

Public Health Relevance

Bioinformatics is increasingly important in cancer research and is having significant impact on basic, clinical,and population-based research as large amounts of data become available. The Bioinformatics Core also plays a central role in serving the needs of the other shared resources of the HCCC.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Iowa
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Holahan, Heather M; Farah, Ronda S; Fitz, Sara et al. (2018) Health-related quality of life in patients with cutaneous T-cell lymphoma? Int J Dermatol 57:1314-1319
Kurth, Ann E; Krist, Alex H; Borsky, Amanda E et al. (2018) U.S. Preventive Services Task Force Methods to Communicate and Disseminate Clinical Preventive Services Recommendations. Am J Prev Med 54:S81-S87
Gadupudi, Gopi S; Elser, Benjamin A; Sandgruber, Fabian A et al. (2018) PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver. Toxicol Sci 163:440-453
Strouse, Christopher; Mangalam, Ashutosh; Zhang, Jun (2018) Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy. Gut Microbes :1-4
White, Katherine A; Swier, Vicki J; Cain, Jacob T et al. (2018) A porcine model of neurofibromatosis type 1 that mimics the human disease. JCI Insight 3:
Tota, Joseph E; Engels, Eric A; Madeleine, Margaret M et al. (2018) Risk of oral tongue cancer among immunocompromised transplant recipients and human immunodeficiency virus-infected individuals in the United States. Cancer 124:2515-2522
Davis, Lauren Z; Cuneo, Michaela; Thaker, Premal H et al. (2018) Changes in spiritual well-being and psychological outcomes in ovarian cancer survivors. Psychooncology 27:477-483
Pearson, Jennifer L; Amato, Michael S; Papandonatos, George D et al. (2018) Exposure to positive peer sentiment about nicotine replacement therapy in an online smoking cessation community is associated with NRT use. Addict Behav 87:39-45
Mobley, Erin M; Foster, Kristin J; Terry, William W (2018) Identifying and Understanding the Gaps in Care Experienced by Adolescent and Young Adult Cancer Patients at the University of Iowa Hospitals and Clinics. J Adolesc Young Adult Oncol 7:592-603
Steinberg, Ryan L; Thomas, Lewis J; O'Donnell, Michael A (2018) Combination Intravesical Chemotherapy for Non-muscle-invasive Bladder Cancer. Eur Urol Focus 4:503-505

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