Abstract

The Bioinformatics Shared Resource (BSR) of the HCCC meets an ever-expanding need from for services to HCCC members who seek to utilize large-volume data and analytical tools. The ongoing need for the BSR is evident from the number of HCCC investigators seeking BSR services and collaboration. BSR personnel actively participate in the NCI's Center for Biomedical Informatics and Information Technology (CBIIT) and National Cancer informatics Program (NCIP) activities. This facilitates their ability to help HCCC members identify tools from other cancer centers that may enhance their own research. The UI has made recent substantial investment in developing Informatics faculty and infrastructure with capabilities that complement the needs of the HCCC. The BSR maintains a collection of computing hardware and software, as well as the human expertise needed to support HCCC members in the design of experiments which require advanced analysis of genomic datasets, support in the deployment and use of existing informatics tools, and custom augmentation of existing tools to meet their needs. The BSR partners with the UI Center for Bioinformatics and Computational Biology (CBCB), as well as the Iowa Institute for Human Genetics (IIHG), to provide a conduit between diverse expertise, tools, and related bioinformatics research seeking to develop new translational research strategies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-18
Application #
9460386
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Grogan, Nicole; Swami, Umang; Bossler, Aaron D et al. (2018) Toxicities with targeted therapies after immunotherapy in metastatic melanoma. Melanoma Res 28:600-604
Meng, Xiangbing; Bi, Jianling; Li, Yujun et al. (2018) AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations. Cancers (Basel) 10:
Klingelhutz, Aloysius J; Gourronc, Francoise A; Chaly, Anna et al. (2018) Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery. Sci Rep 8:523
Tracy, Sean I; Habermann, Thomas M; Feldman, Andrew L et al. (2018) Outcomes among North American patients with diffuse large B-cell lymphoma are independent of tumor Epstein-Barr virus positivity or immunosuppression. Haematologica 103:297-303
Zhu, Yueming; Dean, Angela Elizabeth; Horikoshi, Nobuo et al. (2018) Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. J Clin Invest 128:3682-3691
Ebeid, Kareem; Meng, Xiangbing; Thiel, Kristina W et al. (2018) Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol 13:72-81
Do, Anh-Vu; Geary, Sean M; Seol, Dongrim et al. (2018) Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing. Int J Pharm 539:139-146
Gold, Joshua M; Stuart, Jillian O'Rourke; Thiem, Kelsey C et al. (2018) The unintended impact of smoking-risk information on concerns about radon: A randomized controlled trial. Health Psychol 37:1123-1133
Sarkar, Koustav; Han, Seong-Su; Wen, Kuo-Kuang et al. (2018) R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol 142:219-234
Ramakrishnan, Sreejith; Kockler, Zachary; Evans, Robert et al. (2018) Single-strand annealing between inverted DNA repeats: Pathway choice, participating proteins, and genome destabilizing consequences. PLoS Genet 14:e1007543

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