Abstract

The Tissue Procurement Core is designed to facilitate human specimen-based cancer research. The Core assists Siteman Cancer Center (SCC) investigators in all aspects of prospective study design, from the development of appropriate informed consent documents to protocols for specimen collection, storage and processing. The Core also maintains an archive of several thousand snap frozen tissue specimens representing both common and rare tumor types. Approved investigators may immediately access these specimens for retrospective translational studies. Emphasis is placed on delivering quality-controlled histological sections or purified macromolecules (RNA, genomic DNA, protein extracts) to the investigator for immediate use in histological, genetic or biochemical studies. In addition, the Core provides SCC members access to new technologies for tissue-based research, such as Laser Capture Tissue Microdissection (LCM) and Tissue Microarray (TMA) construction. To date, the Core has assisted several funded SCC members from multiple research programs (both basic science and clinical investigation) in the collection and utilization of human tumor tissue specimens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA091842-04
Application #
6998213
Study Section
Subcommittee G - Education (NCI)
Project Start
2004-09-21
Project End
2009-06-30
Budget Start
2004-09-21
Budget End
2005-06-30
Support Year
4
Fiscal Year
2004
Total Cost
$82,427
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Cherian, Mathew A; Olson, Sydney; Sundaramoorthi, Hemalatha et al. (2018) An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. J Biol Chem 293:6844-6858
Smith, Lee; Ae Lee, Jung; Mun, Junbae et al. (2018) Levels and patterns of self-reported and objectively-measured free-living physical activity among prostate cancer survivors: A prospective cohort study. Cancer :
Burclaff, Joseph; Mills, Jason C (2018) Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine. Dis Model Mech 11:
Ekenga, Christine C; Pérez, Maria; Margenthaler, Julie A et al. (2018) Early-stage breast cancer and employment participation after 2 years of follow-up: A comparison with age-matched controls. Cancer 124:2026-2035
Lin, Huawen; Guo, Suyang; Dutcher, Susan K (2018) RPGRIP1L helps to establish the ciliary gate for entry of proteins. J Cell Sci 131:
Parikh, Rajiv P; Myckatyn, Terence M (2018) Paravertebral blocks and enhanced recovery after surgery protocols in breast reconstructive surgery: patient selection and perspectives. J Pain Res 11:1567-1581
Duan, Chong; Kallehauge, Jesper F; Pérez-Torres, Carlos J et al. (2018) Modeling Dynamic Contrast-Enhanced MRI Data with a Constrained Local AIF. Mol Imaging Biol 20:150-159
Zigler, Rachel E; Madden, Tessa; Ashby, Caitlin et al. (2018) Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial. Obstet Gynecol 132:888-894
Murali, Bhavna; Ren, Qihao; Luo, Xianmin et al. (2018) Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss. Cancer Res 78:5618-5630
Ahmad, Fahd A; Jeffe, Donna B; Plax, Katie et al. (2018) Characteristics of youth agreeing to electronic sexually transmitted infection risk assessment in the emergency department. Emerg Med J 35:46-51

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