Abstract

The Tissue Procurement Core is designed to facilitate human specimen-based cancer research. The Core assists Siteman Cancer Center (SCC) investigators in all aspects of prospective study design, from the development of appropriate informed consent documents to protocols for specimen collection, storage and processing. The Core also maintains an archive of several thousand snap frozen tissue specimens representing both common and rare tumor types. Approved investigators may immediately access these specimens for retrospective translational studies. Emphasis is placed on delivering quality-controlled histological sections or purified macromolecules (RNA, genomic DNA, protein extracts) to the investigator for immediate use in histological, genetic or biochemical studies. In addition, the Core provides SCC members access to new technologies for tissue-based research, such as Laser Capture Tissue Microdissection (LCM) and Tissue Microarray (TMA) construction. To date, the Core has assisted several funded SCC members from multiple research programs (both basic science and clinical investigation) in the collection and utilization of human tumor tissue specimens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA091842-04
Application #
6998213
Study Section
Subcommittee G - Education (NCI)
Project Start
2004-09-21
Project End
2009-06-30
Budget Start
2004-09-21
Budget End
2005-06-30
Support Year
4
Fiscal Year
2004
Total Cost
$82,427
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Waqar, Saiama N; Boehmer, Leigh; Morgensztern, Daniel et al. (2018) Immunogenicity of Influenza Vaccination in Patients With Cancer. Am J Clin Oncol 41:248-253
Duncavage, Eric J; Jacoby, Meagan A; Chang, Gue Su et al. (2018) Mutation Clearance after Transplantation for Myelodysplastic Syndrome. N Engl J Med 379:1028-1041
Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530
Sur, Subhayan; Sasaki, Reina; Devhare, Pradip et al. (2018) Association between MicroRNA-373 and Long Noncoding RNA NORAD in Hepatitis C Virus-Infected Hepatocytes Impairs Wee1 Expression for Growth Promotion. J Virol 92:
Briseño, Carlos G; Satpathy, Ansuman T; Davidson 4th, Jesse T et al. (2018) Notch2-dependent DC2s mediate splenic germinal center responses. Proc Natl Acad Sci U S A 115:10726-10731
Eberth, Jan M; Josey, Michele J; Mobley, Lee R et al. (2018) Who Performs Colonoscopy? Workforce Trends Over Space and Time. J Rural Health 34:138-147
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Alimujiang, Aliya; Colditz, Graham A; Gardner, Jane D et al. (2018) Childhood diet and growth in boys in relation to timing of puberty and adult height: the Longitudinal Studies of Child Health and Development. Cancer Causes Control 29:915-926
Terry, Erin E; Zhang, Xiping; Hoffmann, Christy et al. (2018) Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues. Elife 7:
Soll, Jennifer M; Brickner, Joshua R; Mudge, Miranda C et al. (2018) RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. J Biol Chem 293:13524-13533

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