The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001. The SCC is composed of eight multidisciplinary research programs: Cancer Genetics, Cancer and Developmental Biology, Tumor Immunology, Hematopoietic Development and Malignancy, Cellular Proliferation, Prevention and Control, Translational and Clinical Research, and Oncologic Imaging. Research efforts in the programs are supported by 14 shared resources, two of which are under development: Embryonic Stem Cell Core, Tissue Procurement Core, Molecular Core Laboratory, Multiplexed Gene Analysis Core, Small Animal Cancer Imaging Core, High Speed Cell Sorter Core, Proteomics Core, Hereditary Cancer Core, Pharmacology Core, Bioinformatics Core, Biostatistics Core, Clinical Trials Core, Health Behavior and Outreach Core (developing) and Good Manufacturing Practice Facility (developing). Since submission of the first Cancer Center Support Grant application in October 2000, the SCC has made outstanding progress. Membership has remained relatively stable, with an increase of 18 members since 2000. Interdisciplinary coordination and collaboration has been significantly enhanced through a number of mechanisms, including development of a scientific framework that demonstrates cross-fertilization among the four major areas of the SCC - Basic Science, Translational and Clinical Investigation, Prevention and Control, and Oncologic Imaging. Research is organized around four scientific themes that integrate these areas: Genetic Basis of Cancer; Cancer Biology and Development; Innovative Diagnostics and Therapeutics; and Chemoprevention. Key indicators of progress include an increase in inter-programmatic publications from 23% in 2000 to 28% in 2003; and an increase in the number of integrated, multidisciplinary, programmatic grants from 8 in 2000 to 17 in 2003. This progress is directly attributable to a productive membership that is tightly focused on cancer research, research administrative staff who provide support and guidance in the development of multi-project grants, and engaged Senior Leaders who are committed to fostering collaborative, translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA091842-06S3
Application #
7293970
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
2001-08-02
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
6
Fiscal Year
2006
Total Cost
$21,503
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Cherian, Mathew A; Olson, Sydney; Sundaramoorthi, Hemalatha et al. (2018) An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia. J Biol Chem 293:6844-6858
Smith, Lee; Ae Lee, Jung; Mun, Junbae et al. (2018) Levels and patterns of self-reported and objectively-measured free-living physical activity among prostate cancer survivors: A prospective cohort study. Cancer :
Burclaff, Joseph; Mills, Jason C (2018) Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine. Dis Model Mech 11:
Ekenga, Christine C; Pérez, Maria; Margenthaler, Julie A et al. (2018) Early-stage breast cancer and employment participation after 2 years of follow-up: A comparison with age-matched controls. Cancer 124:2026-2035
Lin, Huawen; Guo, Suyang; Dutcher, Susan K (2018) RPGRIP1L helps to establish the ciliary gate for entry of proteins. J Cell Sci 131:
Parikh, Rajiv P; Myckatyn, Terence M (2018) Paravertebral blocks and enhanced recovery after surgery protocols in breast reconstructive surgery: patient selection and perspectives. J Pain Res 11:1567-1581
Duan, Chong; Kallehauge, Jesper F; Pérez-Torres, Carlos J et al. (2018) Modeling Dynamic Contrast-Enhanced MRI Data with a Constrained Local AIF. Mol Imaging Biol 20:150-159
Zigler, Rachel E; Madden, Tessa; Ashby, Caitlin et al. (2018) Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial. Obstet Gynecol 132:888-894
Murali, Bhavna; Ren, Qihao; Luo, Xianmin et al. (2018) Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss. Cancer Res 78:5618-5630
Ahmad, Fahd A; Jeffe, Donna B; Plax, Katie et al. (2018) Characteristics of youth agreeing to electronic sexually transmitted infection risk assessment in the emergency department. Emerg Med J 35:46-51

Showing the most recent 10 out of 1244 publications