Small Animal Cancer Imaqina Core Small laboratory animal models such as mice, rats and hamsters are widely used throughout the cancer research community at Washington University. Indeed, with the recent revolution in molecular biology, transgenic laboratory animal models, in particular, mice have become an indispensable part of the cancer research armamentarium. Animal models of cancer, however, can present the researcher with significant challenges in deciding how best to evaluate or analyze for the characteristics or effects of interest. Most often, for example, one wishes to follow each of the individual subjects that make up a sample population over an extended time period during which various procedures are carried out. Thus, invasive and/or destructive procedures, especially those that require sacrifice of the subject, are prohibitive. Under these circumstances, nondestructive imaging modalities, such as magnetic resonance imaging, positron emission tomography, and optical imaging are especially valuable. The goals and specific aims of the Small Animal Cancer Imaging Core remain essentially as initially described, namely to bring to the Washington University and St. Louis region cancer research communities a resource that offers state-of-the-art small animal magnetic resonance imaging, positron emission tomography, and optical imaging. As described in this document, optical imaging is being added as a new modality to the Core. The attributes of optical imaging complement those of positron emission tomography and magnetic resonance imaging. In particular, optical imaging offers extremely high signal detection sensitivity with target-specific (molecular) labeling while avoiding the difficulties inherent with radionuciides. Optical Imaging faces challenges in probing deep lying structures, a strength of PET, and in achieving high spatial resolution, a strength of MRI. Thus, the three modalities are complementary, rather than redundant, and offer great opportunities for multi-modal assessment of small animal cancer models.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Mostafa, Heba H; Thompson, Thornton W; Konen, Adam J et al. (2018) Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation. J Virol 92:
Choi, Jaebok; Cooper, Matthew L; Staser, Karl et al. (2018) Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease. Leukemia 32:2483-2494
Bartlett, Nancy L; Costello, Brian A; LaPlant, Betsy R et al. (2018) Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial. Blood 131:182-190
Kalas, Vasilios; Hibbing, Michael E; Maddirala, Amarendar Reddy et al. (2018) Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection. Proc Natl Acad Sci U S A 115:E2819-E2828
Yokoyama, Christine C; Baldridge, Megan T; Leung, Daisy W et al. (2018) LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem 293:6022-6038
Miller, Jessica; Wang, Steven T; Orukari, Inema et al. (2018) Perfusion-based fluorescence imaging method delineates diverse organs and identifies multifocal tumors using generic near-infrared molecular probes. J Biophotonics 11:e201700232
Song, Wilbur M; Joshita, Satoru; Zhou, Yingyue et al. (2018) Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760
Gauvain, Karen; Ponisio, Maria Rosana; Barone, Amy et al. (2018) 18F-FDOPA PET/MRI for monitoring early response to bevacizumab in children with recurrent brain tumors. Neurooncol Pract 5:28-36
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Willet, Spencer G; Lewis, Mark A; Miao, Zhi-Feng et al. (2018) Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J 37:

Showing the most recent 10 out of 1244 publications