The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001. The SCC is composed of eight multidisciplinary research programs: Cancer Genetics, Cancer and Developmental Biology, Tumor Immunology, Hematopoietic Development and Malignancy, Cellular Proliferation, Prevention and Control, Translational and Clinical Research, and Oncologic Imaging. Research efforts in the programs are supported by 14 shared resources, two of which are under development: Embryonic Stem Cell Core, Tissue Procurement Core, Molecular Core Laboratory, Multiplexed Gene Analysis Core, Small Animal Cancer Imaging Core, High Speed Cell Sorter Core, Proteomics Core, Hereditary Cancer Core, Pharmacology Core, Bioinformatics Core, Biostatistics Core, Clinical Trials Core, Health Behavior and Outreach Core (developing) and Good Manufacturing Practice Facility (developing). Since submission of the first Cancer Center Support Grant application in October 2000, the SCC has made outstanding progress. Overall cancer-related grant funding has increased nearly 55% to $119.5 million (total costs), and NCI funding has increased 71% to $41.1 million (total costs). Membership, on the other hand, has remained relatively stable, with an increase of only 18 members since 2000. Interdisciplinary coordination and collaboration has been significantly enhanced through a number of mechanisms, including development of a scientific framework that demonstrates cross-fertilization among the four major areas of the SCC - Basic Science, Translational and Clinical Investigation, Prevention and Control, and Oncologic Imaging. Research is organized around four scientificthemes that integrate these areas: Genetic Basis of Cancer; Cancer Biology and Development; Innovative Diagnostics and Therapeutics; and Chemoprevention. Key indicators of progress include an increase in inter-programmatic publications from 23% in 2000 to 28% in 2003; and an increase in the number of integrated, muttidisciplinary, programmatic grants from 8 in 2000 to 17 in 2003. This progress is directly attributable to a productive membership that is tightly focused on cancer research, research administrative staff who provide support and guidance in the development of multi-project grants, and engaged Senior Leaders who are committed to fostering collaborative, translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA091842-07S2
Application #
7501170
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
2001-08-02
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
7
Fiscal Year
2007
Total Cost
$238,995
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Alimujiang, Aliya; Colditz, Graham A; Gardner, Jane D et al. (2018) Childhood diet and growth in boys in relation to timing of puberty and adult height: the Longitudinal Studies of Child Health and Development. Cancer Causes Control 29:915-926
Terry, Erin E; Zhang, Xiping; Hoffmann, Christy et al. (2018) Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues. Elife 7:
Soll, Jennifer M; Brickner, Joshua R; Mudge, Miranda C et al. (2018) RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. J Biol Chem 293:13524-13533
Ahmed, Abu Shufian Ishtiaq; Dong, Kunzhe; Liu, Jinhua et al. (2018) Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells. Proc Natl Acad Sci U S A 115:E8660-E8667
Brenot, Audrey; Knolhoff, Brett L; DeNardo, David G et al. (2018) SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Oncogenesis 7:32
Gonzalez, Kim L; Ratzel, Sarah E; Burks, Kendall H et al. (2018) A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling. Proc Natl Acad Sci U S A 115:E3163-E3172
VanDussen, Kelli L; Stojmirovi?, Aleksandar; Li, Katherine et al. (2018) Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology 155:815-828
Jin, Ramon U; Mills, Jason C (2018) Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett's Stemming from SPEM. Dig Dis Sci 63:2028-2041
Kulkarni, Devesha H; McDonald, Keely G; Knoop, Kathryn A et al. (2018) Goblet cell associated antigen passages are inhibited during Salmonella typhimurium infection to prevent pathogen dissemination and limit responses to dietary antigens. Mucosal Immunol 11:1103-1113

Showing the most recent 10 out of 1244 publications