The goal of clinical and translational cancer research is to rapidly convert novel advances In bench research to improvements in patient care and to relay findings from clinical studies employing such new and increasingly customized diagnostics and therapeutics back to the bench for further refinement of our understanding of tumorigenesis. To realize this aim, the physician-scientist must be able to Integrate diverse and complex datasets that include clinical information obtained from the patient or participant with the results of routine laboratory tests, imaging, biospecimens, molecular profiling (e.g. microarray analysis, proteomics, and lipidomics), and genome annotation information. These data must be co-analyzed and visualized to gain a comprehensive understanding of the disease process. Furthermore, access to ali of this information and findings from analyses must be seamlessly available to physicians, clinician-scientists, and bench scientists both within and across organizations to reduce the barrier between basic science and clinical research. Given these requirements, the field of biomedical informatics the application of computer science and information technology to the problems of data management In healthcare and biomedical research is a critical and necessary component of effective translational research. To address this need within the SCC and WU, the Bioinformatics Core (now renamed to the Biomedical Informatics Core) was created in 2002. As reflected in the name change, over time, the Core's services have grown to address not only bloinformatics/computational challenges associated with managing, storing, and analyzing high dimensional data sets (e.g. microarray, proteomic, and NextGen sequencing data sets) but also to support syntactic and semantic needs required to represent, store, and share clinical studies/trials and biospecimen data sets. These latter activities and services have been catalyzed by our participation and leadership in the caBlG Initiative as well as the coalescence of informatics at WU into the Center for Biomedical Informatics through the consolidation of personnel, hardware, and software of many different P30-based cores and the CTSA Biomedical Informatics Program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA091842-11
Application #
8380316
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
11
Fiscal Year
2012
Total Cost
$214,669
Indirect Cost
$55,503
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Waqar, Saiama N; Boehmer, Leigh; Morgensztern, Daniel et al. (2018) Immunogenicity of Influenza Vaccination in Patients With Cancer. Am J Clin Oncol 41:248-253
Duncavage, Eric J; Jacoby, Meagan A; Chang, Gue Su et al. (2018) Mutation Clearance after Transplantation for Myelodysplastic Syndrome. N Engl J Med 379:1028-1041
Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530
Sur, Subhayan; Sasaki, Reina; Devhare, Pradip et al. (2018) Association between MicroRNA-373 and Long Noncoding RNA NORAD in Hepatitis C Virus-Infected Hepatocytes Impairs Wee1 Expression for Growth Promotion. J Virol 92:
BriseƱo, Carlos G; Satpathy, Ansuman T; Davidson 4th, Jesse T et al. (2018) Notch2-dependent DC2s mediate splenic germinal center responses. Proc Natl Acad Sci U S A 115:10726-10731
Eberth, Jan M; Josey, Michele J; Mobley, Lee R et al. (2018) Who Performs Colonoscopy? Workforce Trends Over Space and Time. J Rural Health 34:138-147
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Alimujiang, Aliya; Colditz, Graham A; Gardner, Jane D et al. (2018) Childhood diet and growth in boys in relation to timing of puberty and adult height: the Longitudinal Studies of Child Health and Development. Cancer Causes Control 29:915-926
Terry, Erin E; Zhang, Xiping; Hoffmann, Christy et al. (2018) Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues. Elife 7:
Soll, Jennifer M; Brickner, Joshua R; Mudge, Miranda C et al. (2018) RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. J Biol Chem 293:13524-13533

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