Abstract

The Cancer Center Pharmacokinetics Shared Resource facility will provide the resources and experienced personnel to perform kinetic analyses for clinical and preclinical chemotherapeutic drug development studies. In addition to providing basic pharmacokinetic services, this facility is intended to encourage and facilitate all areas of cancer research, including basic and translational research, by providing a range of analytical services such as high-performance liquid chromatography (HPLC) and atomic absorption spectrophotometry (AA). The Cancer Center kinetics facility will, for example provide the equipment and in the personnel expertise for sample storage and preparation, analyses of chemotherapeutic drugs and related compounds, and interpretation of pharmacokinetic, pharmacodynamic, and mass spectral data. This facility will also provide consultation services for pharmacokinetic research project methods, study design, kinetic sampling schedules, protocol review, and will collaborate in manuscript preparation. The kinetics facility direction will meet regularly with members of the Division of Hematology and Oncology and the Cancer Therapeutics Program to discuss pharmacologically relevant issues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
1P30CA093373-01
Application #
6599379
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-07-01
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Dou, John; Schmidt, Rebecca J; Benke, Kelly S et al. (2018) Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation. Epigenetics 13:108-116
Couto, K M; Moore, P F; Zwingenberger, A L et al. (2018) Clinical characteristics and outcome in dogs with small cell T-cell intestinal lymphoma. Vet Comp Oncol 16:337-343
Xue, Xiangdong; Huang, Yee; Wang, Xinshuai et al. (2018) Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy. Biomaterials 161:203-215
Ho, Pui Yan; Duan, Zhijian; Batra, Neelu et al. (2018) Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy. J Pharmacol Exp Ther 365:494-506
Zuo, Yang; Qi, Jinyi; Wang, Guobao (2018) Relative Patlak plot for dynamic PET parametric imaging without the need for early-time input function. Phys Med Biol 63:165004
McGee, Heather M; Daly, Megan E; Azghadi, Sohelia et al. (2018) Stereotactic Ablative Radiation Therapy Induces Systemic Differences in Peripheral Blood Immunophenotype Dependent on Irradiated Site. Int J Radiat Oncol Biol Phys 101:1259-1270
Klapheke, Amy; Yap, Stanley A; Pan, Kevin et al. (2018) Sociodemographic disparities in chemotherapy treatment and impact on survival among patients with metastatic bladder cancer. Urol Oncol 36:308.e19-308.e25
Pol, Arjan; Renkema, G Herma; Tangerman, Albert et al. (2018) Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. Nat Genet 50:120-129
Wang, Yuru; Park, SeHee; Beal, Peter A (2018) Selective Recognition of RNA Substrates by ADAR Deaminase Domains. Biochemistry 57:1640-1651
Campbell, Mel; Watanabe, Tadashi; Nakano, Kazushi et al. (2018) KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation. Nat Commun 9:49

Showing the most recent 10 out of 836 publications