The overall goal of the Population Sciences and Health Disparities Program is to conduct research to delineate and mitigate factors that affect the occurrence (or non-occurrence) of cancer in human populations and their differential manifestations in health status to ultimately reduce avoidable cancer incidence, morbidity, mortality, and to improve the quality of life for those affected by cancer (i.e. survivors and their families). Members from a variety of disciplines contribute their expertise to elucidating variabilities in cancer risk among human populations due to (A) behavioral, socio-demographic, and cultural factors;and/or (B) due to health systems factors. The Program's major research accomplishments include (1) Delineating tobacco as the key to reducing cancer through policy and practice interventions;(2) Delineating new cancer disparities across racial/ethnic and socio-demographic populations and across multiple tumor types;(3) Enhancing cancer detection, treatment, and survival through analyses of large datasets;and (4) Systematically delineating and mitigating hepatitis B viral infections as a pathway to reduce liver cancer disparities. The program has six intervention research grants focused on mitigating cancer health disparities among African Americans, American Indians, Asian Americans, and Latinos. Our P01program project, """"""""Liver Cancer Control Interventions for Asian Americans"""""""" is the only community-based program project. We are funded as the """"""""National Center for Reducing Asian American Cancer Health Disparities"""""""". The foundation of our research efforts are our multidisciplinary approach, our collaboration with registry epidemiologists, and our use of data from longitudinal cohort studies. The program has 24 members with affiliations to 13 different departments at UC Davis, LLNL, Kaiser Permanante, and CADHS. It has 14 NCl-funded projects for $3.5 million ADC (total peer-reviewed funding, $5.6 million ADC). The group has 322 publications for the last funding period;23% are inter-programmatic and 13% are intra-programmatic.
The Population Sciences and Health Disparities Program aims to conduct research and disseminate its findings that provide empirically-based insights that can lead to earlier cancer detection, improve the quality of life and care for cancer survivors and their families, enroll more minority patients into cancer clinical trials, and foster transdisciplinary team science approaches to reducing the cancer burden.
|Matsumoto, Collin; Jiang, Yan; Emathinger, Jacqueline et al. (2018) Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. Stem Cells 36:868-880|
|Turner, David C; Kondic, Anna G; Anderson, Keaven M et al. (2018) Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance. Clin Cancer Res 24:5841-5849|
|Long, Qilai; Lin, Tzu-Yin; Huang, Yee et al. (2018) Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. Nanomedicine 14:789-799|
|Gandara, David R; Riess, Jonathan W; Lara Jr, Primo N (2018) In Search of an Oncogene Driver for Squamous Lung Cancer. JAMA Oncol 4:1197-1198|
|Riess, Jonathan W; Gandara, David R; Frampton, Garrett M et al. (2018) Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC. J Thorac Oncol 13:1560-1568|
|Withers, Sita S; Moore, Peter F; Chang, Hong et al. (2018) Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol 87:64-74|
|Zhang, Jin; Xu, Enshun; Ren, Cong et al. (2018) Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. Cancer Res 78:1511-1521|
|Rowson-Hodel, A R; Wald, J H; Hatakeyama, J et al. (2018) Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene 37:197-207|
|Wang, Minan; Yao, Li-Chin; Cheng, Mingshan et al. (2018) Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J 32:1537-1549|
|York, D; Sproul, C D; Chikere, N et al. (2018) Expression and targeting of transcription factor ATF5 in dog gliomas. Vet Comp Oncol 16:102-107|
Showing the most recent 10 out of 836 publications