The overall goal of the Population Sciences and Health Disparities Program is to conduct research to delineate and mitigate factors that affect the occurrence (or non-occurrence) of cancer in human populations and their differential manifestations in health status to ultimately reduce avoidable cancer incidence, morbidity, mortality, and to improve the quality of life for those affected by cancer (i.e. survivors and their families). Members from a variety of disciplines contribute their expertise to elucidating variabilities in cancer risk among human populations due to (A) behavioral, socio-demographic, and cultural factors;and/or (B) due to health systems factors. The Program's major research accomplishments include (1) Delineating tobacco as the key to reducing cancer through policy and practice interventions;(2) Delineating new cancer disparities across racial/ethnic and socio-demographic populations and across multiple tumor types;(3) Enhancing cancer detection, treatment, and survival through analyses of large datasets;and (4) Systematically delineating and mitigating hepatitis B viral infections as a pathway to reduce liver cancer disparities. The program has six intervention research grants focused on mitigating cancer health disparities among African Americans, American Indians, Asian Americans, and Latinos. Our P01program project, """"""""Liver Cancer Control Interventions for Asian Americans"""""""" is the only community-based program project. We are funded as the """"""""National Center for Reducing Asian American Cancer Health Disparities"""""""". The foundation of our research efforts are our multidisciplinary approach, our collaboration with registry epidemiologists, and our use of data from longitudinal cohort studies. The program has 24 members with affiliations to 13 different departments at UC Davis, LLNL, Kaiser Permanante, and CADHS. It has 14 NCl-funded projects for $3.5 million ADC (total peer-reviewed funding, $5.6 million ADC). The group has 322 publications for the last funding period;23% are inter-programmatic and 13% are intra-programmatic.

Public Health Relevance

The Population Sciences and Health Disparities Program aims to conduct research and disseminate its findings that provide empirically-based insights that can lead to earlier cancer detection, improve the quality of life and care for cancer survivors and their families, enroll more minority patients into cancer clinical trials, and foster transdisciplinary team science approaches to reducing the cancer burden.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA093373-12
Application #
8743642
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
$22,223
Indirect Cost
$7,745
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Matsumoto, Collin; Jiang, Yan; Emathinger, Jacqueline et al. (2018) Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. Stem Cells 36:868-880
Turner, David C; Kondic, Anna G; Anderson, Keaven M et al. (2018) Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance. Clin Cancer Res 24:5841-5849
Long, Qilai; Lin, Tzu-Yin; Huang, Yee et al. (2018) Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. Nanomedicine 14:789-799
Gandara, David R; Riess, Jonathan W; Lara Jr, Primo N (2018) In Search of an Oncogene Driver for Squamous Lung Cancer. JAMA Oncol 4:1197-1198
Riess, Jonathan W; Gandara, David R; Frampton, Garrett M et al. (2018) Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC. J Thorac Oncol 13:1560-1568
Withers, Sita S; Moore, Peter F; Chang, Hong et al. (2018) Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol 87:64-74
Zhang, Jin; Xu, Enshun; Ren, Cong et al. (2018) Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN. Cancer Res 78:1511-1521
Rowson-Hodel, A R; Wald, J H; Hatakeyama, J et al. (2018) Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene 37:197-207
Wang, Minan; Yao, Li-Chin; Cheng, Mingshan et al. (2018) Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J 32:1537-1549
York, D; Sproul, C D; Chikere, N et al. (2018) Expression and targeting of transcription factor ATF5 in dog gliomas. Vet Comp Oncol 16:102-107

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