The central goal of the Population Sciences and Health Disparities (PSHD) research program is to conduct and translate research that will ?avoid, abate, and/or ameliorate the cancer burden in our catchment area and beyond.? This central goal is operationalized through conducting research that delineates and mitigates factors that affect the occurrence of cancer in human populations to ultimately reduce avoidable cancer incidence, morbidity, mortality, and to improve the quality of life for those affected by cancer (i.e., survivors and their families). The Program has three Specific Aims that cohesively tie and frame its members' research contributions: (1) Delineating factors affecting cancer occurrence or non-occurrence in human populations especially through elucidating biological, genetic, and molecular precursors; (2) Mitigating the cancer burden in human populations through intervention research in both community and health system settings; and (3) Contributing impactful findings that lead to formulation of evidence-based guidelines, practices, or policies that advance cancer control and prevention for our catchment area and beyond. We describe how our members' multiple research findings are substantially achieving these Aims as well as addressing the cancer burden in our catchment area. Among our members' numerous achievements in this cycle, our research leadership in developing the empirical bases for breast cancer screening guidelines and in mitigating Asian American cancer health disparities exemplifies our national prominence in Population Sciences and Health Disparities respectively. PROGRAM ASPECTS Co-leaders: Moon S. Chen, Jr., PhD, MPH and Bradley Pollock, PhD, MPH Members: 33 Total Grant Funding (ADC): $8.7 million Total Peer-Reviewed Funding (ADC): $5.3 million Total NCI funding (ADC): $1.8 million Total No. Publications: 658 Inter-programmatic publications: 178 (27.1%) Intra-programmatic publications: 67 (10.2%) Multi-institutional publications: 380 (58%) Overall membership and grant funding increased since 2010. In the prior cycle, the Program had 24 members and $5.9 million from peer-reviewed funds and $61,000 in non-peer reviewed direct costs in funding. In the current cycle, PSHD has 33 members, 25 of whom are Principal Investigators and are drawn from 12 departments including 4 divisions in the Department of Internal Medicine through 5 colleges/schools. In annual direct costs dollars for the period, 7/1/14-6/30/15, PSHD members generated $5,307,312 peer- reviewed funding ($1,770,383 based on 21 projects from the NCI) and $3,357,762 non-peer-reviewed for a total of $8,665,074. While NCI funding declined in dollars, the number of NCI-funded projects in this period, 21, exceeded the number (14) in the prior cycle. Members authored 658 papers versus 322 in the prior cycle (2010; a 51% increase); intra-programmatic publication which were slightly lower than previously (10.2% versus 13%), however inter-programmatic publications increased (27.1% versus 23%). Multi-Institutional publications were at 58%.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA093373-18
Application #
9993306
Study Section
Subcommittee J - Population and Patient-Oriented Training (NCI)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Campbell, Mel; Watanabe, Tadashi; Nakano, Kazushi et al. (2018) KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation. Nat Commun 9:49
Vogel Ciernia, Annie; Careaga, Milo; LaSalle, Janine M et al. (2018) Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism. Glia 66:505-521
Li, Peng-Cheng; Tu, Mei-Juan; Ho, Pui Yan et al. (2018) Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells. Drug Metab Dispos 46:2-10
Lucchesi, Christopher A; Zhang, Jin; Ma, Buyong et al. (2018) Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression. Cancer Res :
Kiuru, Maija; Tartar, Danielle M; Qi, Lihong et al. (2018) Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features. J Am Acad Dermatol 79:221-229
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Fishman, Scott M; Carr, Daniel B; Hogans, Beth et al. (2018) Scope and Nature of Pain- and Analgesia-Related Content of the United States Medical Licensing Examination (USMLE). Pain Med 19:449-459
Lewis, Daniel D; Chavez, Michael; Chiu, Kwan Lun et al. (2018) Reconfigurable Analog Signal Processing by Living Cells. ACS Synth Biol 7:107-120
Braithwaite, Dejana; Miglioretti, Diana L; Zhu, Weiwei et al. (2018) Family History and Breast Cancer Risk Among Older Women in the Breast Cancer Surveillance Consortium Cohort. JAMA Intern Med 178:494-501
Unger, Jakob; Sun, Tianchen; Chen, Yi-Ling et al. (2018) Method for accurate registration of tissue autofluorescence imaging data with corresponding histology: a means for enhanced tumor margin assessment. J Biomed Opt 23:1-11

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