Traditional cancer research involves the study of cancer biology at the cellular, organ, and systemic level. In light of the technological developments in engineering, physics, lasers, imaging systems, biosensing and bioMEMS devices, advanced microscopy systems, drug delivery systems and nanotechnology, the Biomedical Technology Program (BTP) is organized with the goals of capitalizing on the tools and technologies developed by engineering and physical scientists by applying these devices and concepts towards the overall reduction of cancer morbidity and mortality. Currently, the BTP incorporates five scientific themes that capture the breadth of expertise and technologies available to the program. The five themes are: (1) Research and Diagnostic Technologies, (2) Technologies for Whole Body/Organ Imaging, (3) Technologies for Cancer Therapy, (4) Biomarker Discovery and Development, and (5) Biosensing Technologies. The BTP has 34 members with expertise across broad areas of engineering science, physical science and medical science. The BTP includes members from eleven different research and academic departments and four different schools and research centers at UC Davis and Lawrence Livermore National Laboratory (LLNL). This includes the College of Engineering (in particular the Departments of Biomedical Engineering and Mechanical and Aeronautical Engineering), the School of Medicine (in particular Radiology, Radiation Oncology, Internal Medicine, General Surgery, Neurological Surgery), the School of Veterinary Medicine, and LLNL. The BTP also includes members who are primarily clinicians, who play an important role in ensuring the program is addressing cancer-relevant questions, and a critical role in helping technical members of the program move new technologies into successful early phase clinical testing in patients. Thus, the expertise of our members spans a wide range of scientific disciplines and fields bridging from the engineering and physical sciences to the medical and veterinary sciences. PROGRAM ASPECTS Co-leaders: Simon Cherry, PhD; Laura Marcu, PhD Members: 34 Total Grant Funding (ADC): $7.8 million Total Peer-Reviewed Funding (ADC): $7.2 million Total NCI funding (ADC): $3.0 million Total No. Publications: 644 Inter-programmatic publications: 235 (37%) Intra-programmatic publications: 121 (19%) Multi-institutional publications: 262 (41%)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA093373-18
Application #
9993310
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Weiss, Robert H (2018) Metabolomics and Metabolic Reprogramming in Kidney Cancer. Semin Nephrol 38:175-182
Shih, Tsung-Chieh; Liu, Ruiwu; Wu, Chun-Te et al. (2018) Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion. Clin Cancer Res 24:4319-4331
Arun, Adith S; Tepper, Clifford G; Lam, Kit S (2018) Identification of integrin drug targets for 17 solid tumor types. Oncotarget 9:30146-30162
Hegde, John V; Shaverdian, Narek; Daly, Megan E et al. (2018) Patient-reported quality-of-life outcomes after de-escalated chemoradiation for human papillomavirus-positive oropharyngeal carcinoma: Findings from a phase 2 trial. Cancer 124:521-529
Jerant, Anthony; Fenton, Joshua J; Kravitz, Richard L et al. (2018) Association of Clinician Denial of Patient Requests With Patient Satisfaction. JAMA Intern Med 178:85-91
Tepper, Clifford G; Dang, Julie H T; Stewart, Susan L et al. (2018) High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease. Cancer 124 Suppl 7:1583-1589
Besprozvannaya, Marina; Dickson, Eamonn; Li, Hao et al. (2018) GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife 7:
Kirschbaum, Mark H; Frankel, Paul; Synold, Timothy W et al. (2018) A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study. Br J Haematol 180:445-448
Matsumoto, Collin; Jiang, Yan; Emathinger, Jacqueline et al. (2018) Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate. Stem Cells 36:868-880
Turner, David C; Kondic, Anna G; Anderson, Keaven M et al. (2018) Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance. Clin Cancer Res 24:5841-5849

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