KECK-UNM SMALL ANIMAL MODELS & IMAGING SHARED RESOURCE ABSTRACT The University of New Mexico Cancer Center (UNMCC) Keck-UNM Small Animal Models and Imaging (Animal Models) Shared Resource provides cost-effective comprehensive services in the development and use of animal models for basic, translational, and pre-clinical cancer research. The Resource was established as a Developing Resource in July 2006 with funds from the UNMCC and the NCI P30 Cancer Center Support Grant and has evolved to offer a wide range of services, including consultation, protocol development and guidance through the compliance process, animal housing (provided in collaboration through the Animal Resource Facility), husbandry, handling, treatment, monitoring, surgery, and dissection/necropsy. The Resource has a comprehensive range of state-of-the-art capabilities in small-animal imaging, including PET/SPECT/CT modalities, MRI and other magnetic-based imaging modalities. The small-animal models component of the Resource specializes in genetically modified, chemically induced, and xenograft models of cancer, including orthotopic models and immunodeficient models for growth of primary human tumor tissues. The small-animal imaging component of the Resource is involved in emerging PET/SPECT/CT and bioluminescence/ fluorescence imaging and therapeutic research, and offers users a broad range of radiolabeling and in vivo analysis. In 2014, UNMCC purchased a new bioluminescence/fluorescence imaging instrument to track tumor progression, metastasis, and labeled nanotherapeutics and a new small animal irradiator, which will enhance development and analysis of humanized mouse models and hematopoietic cell engraftment. In 2014, the Cancer Center also recruited a dedicated Veterinary Pathologist to join the Resource to provide support to UNMCC investigators. Two faculty co-Directors, Helen Hathaway, PhD and Jeffrey Norenberg, PhD, PharmD, direct the Resource and services are provided by experienced technical staff. The Resource Directors are committed to continual development of state-of-the-science techniques to enhance UNMCC Research Programs. The Resource disseminates information about new technologies and models by maintaining an up-to-date web page, hosting regular open houses, and by giving presentations at UNMCC meetings and retreats. Reservations, billing and usage are tracked through a centralized on-line system. During the previous 5-year project period, 13 UNMCC members from 3 UNMCC Research Programs used the Resource, resulting in a total of 27 publications, of which 5 are presently pending PMCIDs. In the reporting year of July 2013 ? June 2014, UNMCC members were responsible for 83% of total Resource usage and were supported by 29 cancer-focused, peer-reviewed grants. Utilization of the Resource is expected to grow significantly in the next project period with the recent recruitment of many new UNMCC investigators developing and utilizing animal models in their research.
| Peretti, Amanda S; Dominguez, Dayna; Grimes, Martha M et al. (2018) The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice. Am J Pathol 188:515-524 |
| Brandsma, Arianne M; Schwartz, Samantha L; Wester, Michael J et al. (2018) Mechanisms of inside-out signaling of the high-affinity IgG receptor Fc?RI. Sci Signal 11: |
| Zheng, Handong; Wu, Dandan; Wu, Xiang et al. (2018) Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway. Sci Rep 8:8905 |
| Ray, Anita L; Berggren, Kiersten L; Restrepo Cruz, Sebastian et al. (2018) Inhibition of MK2 suppresses IL-1?, IL-6, and TNF-?-dependent colorectal cancer growth. Int J Cancer 142:1702-1711 |
| Hudson, Laurie G; Gillette, Jennifer M; Kang, Huining et al. (2018) Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. Cancers (Basel) 10: |
| Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934 |
| Palsuledesai, Charuta C; Surviladze, Zurab; Waller, Anna et al. (2018) Activation of Rho Family GTPases by Small Molecules. ACS Chem Biol 13:1514-1524 |
| Sallmyr, Annahita; Tomkinson, Alan E (2018) Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. J Biol Chem 293:10536-10546 |
| Kumar, Suresh; Jain, Ashish; Farzam, Farzin et al. (2018) Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. J Cell Biol 217:997-1013 |
| Vicuña, Belinda; Delaney, Harold D; Flores, Kristina G et al. (2018) Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families. J Community Genet 9:81-92 |
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