The Program in Radiation Biology is focused on ways in which the effectiveness of radiotherapy canincrease local tumor control and survival of cancer patients. Three different approaches are beingpursued to achieve this goal: 1) Development of pharmacologic and biologic agents to combine withradiotherapy and chemotherapy to improve local tumor control and prevent metastatic spread. 2)Development of new approaches and clinical trials to administer radiotherapy. 3) The identification ofgenetic determinants that influence the tumor response to radiation or the combination of chemotherapyand radiation using yeast and mammalian genetics. The research of program members has resulted in aseries of important findings that include the regulation of stem cell differentiation by hypoxia,identifying a serum biomarker for tumor hypoxia, developing hypoxic specific cytotoxins for cancertherapy, identifying new genes that are essential for DNA repair and adaptation to stress, defining therole of p53 in global genomic DNA repair, generation of mouse models to dissect the role of p53transactivation and p53 target genes in in vivo stress responses, the use of radiosurgery to treat pancreaticcancer, liver, lung and prostate cancer, and developing molecular and functional imaging techniques todirect the delivery of radiotherapy. The 23 program members representing the School of Medicine andDepartment of Biological Sciences in the School of Humanities and Sciences are highly motivated todevelop new targeted therapeutics to combine with radiotherapy and are well supported by twoprogram project grants and $4.3 million in NCI funding. During the last five years, the program memberspublished 188 papers. With the support of the Cancer Center, the role of Radiation Biology in tumorimmunity, stem cell recruitment and differentiation, and functional imaging will be further developedand expanded. In particular, the Cancer Center will greatly aid in translating many of the laboratorybasedfindings to increase the effectiveness of radiotherapy into the clinic.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Stanford University
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Nair, Viswam S; Sundaram, Vandana; Desai, Manisha et al. (2018) Accuracy of Models to Identify Lung Nodule Cancer Risk in the National Lung Screening Trial. Am J Respir Crit Care Med 197:1220-1223
She, Richard; Jarosz, Daniel F (2018) Mapping Causal Variants with Single-Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change. Cell 172:478-490.e15
Champion, Magali; Brennan, Kevin; Croonenborghs, Tom et al. (2018) Module Analysis Captures Pancancer Genetically and Epigenetically Deregulated Cancer Driver Genes for Smoking and Antiviral Response. EBioMedicine 27:156-166
Zhou, Mu; Leung, Ann; Echegaray, Sebastian et al. (2018) Non-Small Cell Lung Cancer Radiogenomics Map Identifies Relationships between Molecular and Imaging Phenotypes with Prognostic Implications. Radiology 286:307-315
Pollom, Erqi L; Fujimoto, Dylann K; Han, Summer S et al. (2018) Newly diagnosed glioblastoma: adverse socioeconomic factors correlate with delay in radiotherapy initiation and worse overall survival. J Radiat Res 59:i11-i18
Nørgaard, Caroline Holm; Jakobsen, Lasse Hjort; Gentles, Andrew J et al. (2018) Subtype assignment of CLL based on B-cell subset associated gene signatures from normal bone marrow - A proof of concept study. PLoS One 13:e0193249
Im, Hogune; Rao, Varsha; Sridhar, Kunju et al. (2018) Distinct transcriptomic and exomic abnormalities within myelodysplastic syndrome marrow cells. Leuk Lymphoma 59:2952-2962
Huang, Min; Zhu, Li; Garcia, Jacqueline S et al. (2018) Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells. Oncotarget 9:11665-11676
Chiou, Shin-Heng; Dorsch, Madeleine; Kusch, Eva et al. (2018) Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. Sci Rep 8:14008
Breslow, David K; Hoogendoorn, Sascha; Kopp, Adam R et al. (2018) A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nat Genet 50:460-471

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