The Biostatistics Resource is a new resource that arose from existing successful programs in the Biostatistics, Informatics, and Data Management Section of the Breast Center, and in the Bioinformatics Resource of the Prostate SPORE. This BCMCC Resource currently comprises three PhD faculty, one MS faculty, and three MS staff biostatisticians. The Resource is already well-integrated into the Cancer Center, providing support to investigators in every Program during the last year and coauthoring 22 peer-reviewed publications with Cancer Center investigators. More than 70% of the current personnel budget for the Resource was covered by charge-backs on peer-reviewed funding. The Biostatistics Resource is led by Susan G. Hilsenbeck, Ph.D., who has extensive experience in organizing and providing biostatistical and data management support for both cancer clinical trials and basic research studies. The primary purpose of the Resource is to support the research efforts of the Cancer Center through collaboration on biostatistical aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical assistance including general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development, and interpretation;education and training;statistical review for PRMS;and consultation on database development. In order to truly fulfill this purpose, the Resource will have to expand. We will first recruit additional faculty with expertise in clinical trials in order to meet the pressing and immediate need in this area. Subsequent recruits will address unmet needs in more basic and genomic studies. We are also reaching out to other quantitative scientists within the College who have special expertise that may benefit Cancer Center investigators. In this way the Resource will provide Cancer Center investigators with strong, broad-based biostatistical expertise.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA125123-03
Application #
7900432
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$190,532
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Mundt, Filip; Rajput, Sandeep; Li, Shunqiang et al. (2018) Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers. Cancer Res 78:2732-2746
Nair, Amritha; Chung, Hsiang-Ching; Sun, Tingting et al. (2018) Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med 24:505-511
Yu, Wangie; Chen, Yunyun; Dubrulle, Julien et al. (2018) Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism. Sci Rep 8:4306
Singh, Ramesh; Karri, Dileep; Shen, Hong et al. (2018) TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest 128:3129-3143
Berntsson, Shala G; Merrell, Ryan T; Amirian, E Susan et al. (2018) Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study. J Neurol 265:1432-1442
Chen, Fengju; Zhang, Yiqun; Gibbons, Don L et al. (2018) Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases. Clin Cancer Res 24:2182-2193
Maldonado, Maria; Molfese, David L; Viswanath, Humsini et al. (2018) The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study. J Cachexia Sarcopenia Muscle 9:497-504
Richards, JoAnne S; Ren, Yi A; Candelaria, Nicholes et al. (2018) Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update. Endocr Rev 39:1-20
Kogiso, Mari; Qi, Lin; Braun, Frank K et al. (2018) Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models. Clin Cancer Res 24:2159-2170
Takahashi, Hannah; Cornish, Alex J; Sud, Amit et al. (2018) Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Sci Rep 8:2339

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