The Biostatistics Resource is a new resource that arose from existing successful programs in the Biostatistics, Informatics, and Data Management Section of the Breast Center, and in the Bioinformatics Resource of the Prostate SPORE. This BCMCC Resource currently comprises three PhD faculty, one MS faculty, and three MS staff biostatisticians. The Resource is already well-integrated into the Cancer Center, providing support to investigators in every Program during the last year and coauthoring 22 peer-reviewed publications with Cancer Center investigators. More than 70% of the current personnel budget for the Resource was covered by charge-backs on peer-reviewed funding. The Biostatistics Resource is led by Susan G. Hilsenbeck, Ph.D., who has extensive experience in organizing and providing biostatistical and data management support for both cancer clinical trials and basic research studies. The primary purpose of the Resource is to support the research efforts of the Cancer Center through collaboration on biostatistical aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical assistance including general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development, and interpretation;education and training;statistical review for PRMS;and consultation on database development. In order to truly fulfill this purpose, the Resource will have to expand. We will first recruit additional faculty with expertise in clinical trials in order to meet the pressing and immediate need in this area. Subsequent recruits will address unmet needs in more basic and genomic studies. We are also reaching out to other quantitative scientists within the College who have special expertise that may benefit Cancer Center investigators. In this way the Resource will provide Cancer Center investigators with strong, broad-based biostatistical expertise.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA125123-03
Application #
7900432
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$190,532
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Kundu, Samrat T; Grzeskowiak, Caitlin L; Fradette, Jared J et al. (2018) TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. Nat Commun 9:2731
Kim, Myunghoo; Galan, Carolina; Hill, Andrea A et al. (2018) Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity 49:151-163.e5
Mamonkin, Maksim; Mukherjee, Malini; Srinivasan, Madhuwanti et al. (2018) Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies. Cancer Immunol Res 6:47-58
Morriss, Ginny R; Rajapakshe, Kimal; Huang, Shixia et al. (2018) Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet 27:2789-2804
Lanza, Denise G; Gaspero, Angelina; Lorenzo, Isabel et al. (2018) Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. BMC Biol 16:69
Jeong, Mira; Park, Hyun Jung; Celik, Hamza et al. (2018) Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. Cell Rep 23:1-10
Boudreaux, Seth P; Duren, Ryan P; Call, Steven G et al. (2018) Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia. Leukemia :
Sukumaran, Sujita; Watanabe, Norihiro; Bajgain, Pradip et al. (2018) Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment. Cancer Discov 8:972-987
Kaochar, Salma; Mitsiades, Nicholas (2018) A Novel Mechanism to Drive Castration-Resistant Prostate Cancer. Trends Endocrinol Metab 29:366-368
Johnston, A N; Bu, W; Hein, S et al. (2018) Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. Breast Cancer Res 20:42

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