Recent data indicate dramatic increases in both awareness and use of electronic cigarettes (e-cigarettes) in the USA. Moreover, e-cigarette use is higher among current smokers than former- or never-smokers. This is of considerable public health significance since very little is known about the effects that e-cigarettes have on brain functioning, behavior, and physiology. This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and project 2 will be a community-based experiment. For the laboratory-based experiments, non-treatment seeking cigarette smokers (N=90/group) will be evaluated after exposure to e-cigarettes (0 or 18 mg) or their own cigarette on three separate visits: This will allow us to directly compare and evaluate e-cigarettes against smokers'preferred brand of cigarettes. In the first experiment (Project 1a), behavioral and physiological responses to smoking cues will be evaluated using virtual reality cues. In addition, this experiment will assess changes in smoking severity via a dual-component self-administration session in conjunction with the CReSS device to assess smoking topography. In the second experiment (Project 1 b), functional magnetic resonance imaging will be used to measure brain responses to general reward, and to pictures of cigarettes and e-cigarettes. In addition, pictures displaying the Surgeon General's messages about cigarette smoking will be shown to evaluate perceptions about adverse health consequences of cigarettes and e-cigarettes. Upon completion of either laboratory-based experiment, all participants will proceed into the community-based study, project 2, in which all individuals (N=180) will be presented with e-cigarettes (18 mg). In this study, participants will visit the clinic once weekly for 4 week as well as 1 month follow-up. Daily assessments will be conducted using ecological momentary assessment (EMA). EMA assessments will include initiation and continuation of e-cigarette use, assessments of changes in use of own cigarettes, and assessments of perceptions, satisfaction and acceptability of e-cigarettes. Additionally, we will evaluate continuation of e-cigarette use a 1-month follow-up.

Public Health Relevance

This P30 application includes two key projects: project 1 will consist of two laboratory-based experiments and projects will be a community-based experiment. The proposed experiments will provide invaluable and detailed data to the FDA on e-cigarette initiation, use, multiple use, and perceptions in cigarette smokers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA125123-08S2
Application #
8642296
Study Section
Special Emphasis Panel (ZRG1-RPHB-K (40))
Program Officer
Shafik, Hasnaa
Project Start
2007-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
8
Fiscal Year
2014
Total Cost
$575,470
Indirect Cost
$203,060
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Shi, Xiangguo; Kitano, Ayumi; Jiang, Yajian et al. (2018) Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells. Exp Hematol 64:33-44.e5
Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai et al. (2018) Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature 556:249-254
Qin, Liying; Sankaran, Banumathi; Aminzai, Sahar et al. (2018) Structural basis for selective inhibition of human PKG I? by the balanol-like compound N46. J Biol Chem 293:10985-10992
Chapple, Richard H; Tseng, Yu-Jung; Hu, Tianyuan et al. (2018) Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis. Blood Adv 2:1220-1228
Disney-Hogg, Linden; Cornish, Alex J; Sud, Amit et al. (2018) Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med 16:42
Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470
Tan, Xiaochao; Banerjee, Priyam; Liu, Xin et al. (2018) The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest 128:1267-1282
Zhao, Na; Cao, Jin; Xu, Longyong et al. (2018) Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128:1283-1299
Reznik, Ed; Luna, Augustin; Aksoy, B├╝lent Arman et al. (2018) A Landscape of Metabolic Variation across Tumor Types. Cell Syst 6:301-313.e3
Blue, R Eric; Koushik, Amrita; Engels, Nichlas M et al. (2018) Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology. Int J Biochem Cell Biol 105:134-143

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