The Animal Shared Sen/ice at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) is a component of Veterinary Resources, which in turn, is part of the service arm of Comparative Medicine at the University of Maryland School of Medicine (UMSOM). The Animal Shared Service represents more than one-third of Veterinary Resources'total animal operations. The mission of the shared service is to provide comprehensive lab animal services, care, and facilities to members of UMGCC . The goals of the Animal Shared Service are to provide high-quality, extensive services?including animal procurement, husbandry care, medical oversight, microbiological monitoring, pathology services, maintenance of genetically altered and immunodeficient rodent colonies, consultation and collaboration on animal model selection and development, and management of in vivo cancer center research projects. Comparative Medicine is an independent academic division that conducts collaborative and independent research. Established in 1989, it studies the characterization of animal models of human disease for biomedical research and the use of such models to advance understanding of disease or biological processes. Comparative Medicine contributes to UMSOM and UMGCC by providing collaborative research and professional development of veterinary physicians and staff, and is a resource for information and instruction on the use of lab animals in research. Veterinary Resources and the Institutional Care and Use Committee oversee and support all biomedical research projects that use live animals at UMSOM, including animal research carried out by members of UMGCC. The faculty, staff, and students at UMSOM and UMGCC understand that the quality of their research is critically dependant on the quality of lab animal care and use. Furthermore, appreciation of the educational and research missions by the university community at large is enhanced by the assurance that UMSOM and UMGCC sponsor ethical and humane lab animal care.

Public Health Relevance

The Animal Shared Service offers valuable resources to support cancer research by investigators at UMGCC, including providing advice on animal model development;providing veterinary medical care to lab animals used in cancer research;and training investigators in special techniques, such as surgeries, anesthesia, drug delivery methods, and animal handling?all of which are necessary when conducting research on lab animals.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
United States
Zip Code
Furusawa, Aki; Reiser, John; Sadashivaiah, Kavitha et al. (2018) Eomesodermin Increases Survival and IL-2 Responsiveness of Tumor-specific CD8+ T Cells in an Adoptive Transfer Model of Cancer Immunotherapy. J Immunother 41:53-63
Nathenson, Michael J; Conley, Anthony P; Sausville, Edward (2018) Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas. Oncologist 23:71-83
Wang, Lei; Felts, Sara J; Van Keulen, Virginia P et al. (2018) Exploring the effect of library preparation on RNA sequencing experiments. Genomics :
Nathenson, Michael J; Barysauskas, Constance M; Nathenson, Robert A et al. (2018) Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma. World J Surg Oncol 16:203
Sallmyr, Annahita; Tomkinson, Alan E (2018) Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. J Biol Chem 293:10536-10546
Kerr, Candace; Adhikary, Gautam; Grun, Daniel et al. (2018) Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma. Mol Carcinog 57:3-11
Connolly, Sean; Quasi-Woode, Devona; Waldron, Laura et al. (2018) Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae. Genetics 209:801-813
Pauza, C David; Liou, Mei-Ling; Lahusen, Tyler et al. (2018) Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local. Front Immunol 9:1305
Wang, Lei; Felts, Sara J; Van Keulen, Virginia P et al. (2018) Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients. Cancer Res 78:4411-4423
McCusker, Michael G; El Chaer, Firas; Duffy, Alison et al. (2018) Combination of Blinatumomab and Vincristine Sulfate Liposome Injection for Treatment of Relapsed Philadelphia Chromosome Positive B-cell Acute Lymphoblastic Leukemia. Am J Leuk Res 2:

Showing the most recent 10 out of 257 publications