The Radiation Linear Accelerator Shared Service (RLASS) is a resource for supporting radiation studies for investigators at the University of Maryland School of Medicine, including the Mariene and Stewart Greenebaum Cancer Center (UMGCC). The shared service currently operates a state-of-the-art research megavoltage linear accelerator (Varian Medical Systems, Palo Alto, CA) that is capable of delivering photon (6-18 MV) and electron (6-18 MeV) radiation beams. This linear accelerator is equipped with state-of-the-art, onboard imaging capabilities that aid in accurate localization of radiation targets. With this combination of technologies, RLASS can replicate sophisticated treatment modalities that are offered as standard of care to patients undergoing radiation therapy. RLASS is a unique resource because most linear accelerators are typically utilized on a full-time basis for clinical radiation therapy treatments. RLASS offers cell culture irradiation, total and hemi-body irradiation, organ- and tissue-specific irradiation in the form of 3D conformal radiation therapy and intensity-modulated radiation therapy, treatment planning and 3D dose calculation capabilities, and onboard imaging. Highly skilled faculty and staff provide investigators at UMGCC with the expertise to design animal protocols and perform dosimetry calculations and measurements to ensure highly reliable estimates of whole-body, partial-body, and organ-specific doses. The effectiveness of this shared service can be gauged from the fact that it has supported the development of advanced radiation delivery and organ-motion management technologies. In addition, it has supported the development of complex nonhuman primate models of radiation-induced injury.

Public Health Relevance

The availability of the Radiation Linear Accelerator Shared Service is essential to advancing technical developments at UMGCC that will spur the creation of novel treatment radiation delivery methods. The radiation linear accelerator also provides a platform to evaluate models of intervention to prevent radiation injury.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
United States
Zip Code
Wang, Junxiang; Zhao, Liang; Ye, Yanfang et al. (2018) Adverse event detection by integrating twitter data and VAERS. J Biomed Semantics 9:19
Furusawa, Aki; Reiser, John; Sadashivaiah, Kavitha et al. (2018) Eomesodermin Increases Survival and IL-2 Responsiveness of Tumor-specific CD8+ T Cells in an Adoptive Transfer Model of Cancer Immunotherapy. J Immunother 41:53-63
Nathenson, Michael J; Conley, Anthony P; Sausville, Edward (2018) Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas. Oncologist 23:71-83
Wang, Lei; Felts, Sara J; Van Keulen, Virginia P et al. (2018) Exploring the effect of library preparation on RNA sequencing experiments. Genomics :
Nathenson, Michael J; Barysauskas, Constance M; Nathenson, Robert A et al. (2018) Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma. World J Surg Oncol 16:203
Sallmyr, Annahita; Tomkinson, Alan E (2018) Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. J Biol Chem 293:10536-10546
Kerr, Candace; Adhikary, Gautam; Grun, Daniel et al. (2018) Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma. Mol Carcinog 57:3-11
Connolly, Sean; Quasi-Woode, Devona; Waldron, Laura et al. (2018) Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae. Genetics 209:801-813
Pauza, C David; Liou, Mei-Ling; Lahusen, Tyler et al. (2018) Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local. Front Immunol 9:1305
Wang, Lei; Felts, Sara J; Van Keulen, Virginia P et al. (2018) Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients. Cancer Res 78:4411-4423

Showing the most recent 10 out of 257 publications