Program 3. Discovery and Developmental Therapeutics (DDT): The overall scientific goal of the Cancer Discovery and Developmental Therapeutics (DDT) Program is to enhance the discovery of new agents and advance their translation into the prevention and treatment of patients with cancer. The program has two full specific aims, and two major developing aims. The overall goal is to foster a highly collaborative team science environment, building on the existing strong ties with the MPB, CGE and CCPS Programs, to promote molecular target-based cancer drug discovery and to facilitate translational clinical trials for effective therapeutic development. To achieve this goal, the Program is organized with the following foci: (1) To identify small molecule modulators of tumor-addicted signaling pathways for cancer drug discovery;(2) To carry out mechanism-driven clinical trials for cancer drug development to rapidly move new agents to patients;(3) To translate discoveries in cancer immunology into mechanistically driven clinical trials enhancing the therapy of patients with hematologic malignancies and immuno-responsive solid tumors;(4) To test promising agents early in their life cycle in the multi-modality setting using mechanism-based clinical trials in conjunction with optimized chemo-radiation, radiation or surgery. We plan to achieve the goal of developing novel therapeutic approaches to the prevention and treatment of cancer through close intra- and inter-programmatic interactions by focusing on such areas as: (1) chemoprevention, (2) molecularly-targeted therapy, (3) new drug discovery, (4) biological interaction between epithelial and surrounding tissue, (5) nanotherapeutics, (6) cancer immunotherapy, (7) biomedical research platforms using innovative technology to prevent and treat tumors, and (8) translational multimodality research for advanced solid malignancies. The DDT Program comprises a diverse group of 45 members from 15 different departments within the School of Medicine, the School of Public Health and Emory College. The DDT Program has total peerreviewed program funding of $23 M, of which NCI funding represents $17.5M ($13.6M direct). In addition, there is a total of $1.9 M in non-peer-reviewed support from various sources. Program members have published a total of 535 papers during the last five years, of which 47% are intra-programmatic and 53% are inter-programmatic.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Emory University
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Koff, Jean L; Li, Jing-Xia; Zhang, Xinyan et al. (2018) Impact of the posttransplant lymphoproliferative disorder subtype on survival. Cancer 124:2327-2336
Dennison, Cori; King, Adrian R; Rutledge, Hannah et al. (2018) HPV Vaccine-Related Research, Promotion and Coordination in the State of Georgia: A Systematic Review. J Community Health :
Dhere, Vishal; Edelman, Scott; Waller, Edmund K et al. (2018) Myeloablative busulfan/cytoxan conditioning versus reduced-intensity fludarabine/melphalan conditioning for allogeneic hematopoietic stem cell transplant in patients with acute myelogenous leukemia. Leuk Lymphoma 59:837-843
Steuer, Conor E; Griffith, Christopher C; Nannapaneni, Sreenivas et al. (2018) A Correlative Analysis of PD-L1, PD-1, PD-L2, EGFR, HER2, and HER3 Expression in Oropharyngeal Squamous Cell Carcinoma. Mol Cancer Ther 17:710-716
Pillai, Rathi N; Behera, Madhusmita; Owonikoko, Taofeek K et al. (2018) Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature. Cancer 124:271-277
King, Adrian R; Moon, Tamira; Agnew, Gena et al. (2018) Human Papillomavirus Vaccination in Georgia: Evaluating the Georgia HPV Work Group. J Community Health :
Ivanov, Andrei A; Revennaugh, Brian; Rusnak, Lauren et al. (2018) The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery. Bioinformatics 34:1183-1191
Mehta, Neeti D; Haroon, Ebrahim; Xu, Xiaodan et al. (2018) Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results. Brain Behav Immun 73:725-730
Halicek, Martin; Little, James V; Wang, Xu et al. (2018) Tumor Margin Classification of Head and Neck Cancer Using Hyperspectral Imaging and Convolutional Neural Networks. Proc SPIE Int Soc Opt Eng 10576:
Lee, Jocelyn A; Wang, Zhengqi; Sambo, Danielle et al. (2018) Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem 293:9636-9650

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