The developing Bioinformatics Shared Resource in the previous grant submission has been integrated within biostatistics to become the Biostatistics and Bioinformatics Shared Resource (BBISR). With four (full-time) doctoral level faculty biostatisticians, two (part-time) bioinformatics faculty, and two master-level biostatisticians, BBISR staff members collaborate and consult with Winship investigators in the design, conduct, and analysis of preclinical, clinical, laboratory, epidemiologic and molecular cancer investigations. BBISR uses a service support model that draws upon existing Emory University-wide expertise and investment to meet the needs of Winship members. Specifically, BBISR facilitates research by striving to expertly fulfilling the following study components: design (feasibility in meeting study objectives, sample size), recommendations concerning key infrastructure, data analysis, preparations of reports and manuscripts, review of proposals in the Clinical and Translational Research Committee, and development of methods as needed by project. The overall goal of the BBISR is to ensure the use of proper study design and appropriate analysis methods in Winship cancer members'research. BBISR staff members are integrated both locally, within the Winship research programs throughout Emory University, including the Rollins School of Public Health, the Center for Comprehensive Informatics, and with the Atlanta Clinical and Translational Science Institute. Collaborations with Winship investigators have resulted in 51 publications, and BBISR staff members contributing to 38 grant submissions in CY2010. Future plans for this shared resource include the following: strengthening current biostatistics expertise in early phase trial design by a greater integration with genomic data, expanding biostatistics expertise through additional faculty and staff recruitment, building core personnel in bioinformatics, and initiatives towards building devoted informatics support.
The BBISR offers a coordinated approach to cancer research beyond what could be attained by researchers in any single domain. Leveraging its own cancer-specific expertise with the resources of Emory University has helped the BBISR to propose novel solutions to complex problems. In achieving its goals, the BBISR is enabling Winship cancer investigators to achieve theirs.
|Halani, Sameer H; Yousefi, Safoora; Vega, Jose Velazquez et al. (2018) Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways. NPJ Precis Oncol 2:24|
|Ferris, Matthew J; Liu, Yuan; Ao, Jingning et al. (2018) The addition of chemotherapy in the definitive management of high risk prostate cancer. Urol Oncol 36:475-487|
|Halicek, Martin; Little, James V; Wang, Xu et al. (2018) Deformable Registration of Histological Cancer Margins to Gross Hyperspectral Images using Demons. Proc SPIE Int Soc Opt Eng 10581:|
|Cassidy, Richard J; Switchenko, Jeffrey M; El-Deiry, Mark W et al. (2018) Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas. Laryngoscope :|
|Mukherjee, Subhas; Tucker-Burden, Carol; Kaissi, Emily et al. (2018) CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. Cell Rep 23:1651-1664|
|Thompson, Jeffrey A; Christensen, Brock C; Marsit, Carmen J (2018) Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts. Sci Rep 8:5190|
|Sadigh, Gelareh; Holder, Chad A; Switchenko, Jeffrey M et al. (2018) Is there added value in obtaining cervical spine MRI in the assessment of nontraumatic angiographically negative subarachnoid hemorrhage? A retrospective study and meta-analysis of the literature. J Neurosurg 129:670-676|
|Allen, Samuel C; Lohani, Minisha; Hendershot, Kristopher A et al. (2018) Patient perspectives on compensation for biospecimen donation. AJOB Empir Bioeth 9:77-81|
|Cassidy, Richard J; Switchenko, Jeffrey M; Yushak, Melinda L et al. (2018) The importance of surgery in scalp angiosarcomas. Surg Oncol 27:A3-A8|
|Owonikoko, Taofeek K; Busari, Adeniyi K; Kim, Sungjin et al. (2018) Race-, Age-, and Gender-Based Characteristics and Toxicities of Targeted Therapies on Phase I Trials. Oncology 95:138-146|
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