Abstract

The Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC) requests $175,000 in developmental funds, 17.5% of the overall direct Cancer Center Support Grant (CCSG) request, that will be used specifically to: Provide three to five pilot research funding grants to HCC members, a total of $120,000 per year, to promote translational research in high priority areas as articulated by the HCC Senior Leadership ? Recruit one new faculty scientist with an emphasis on translational immunotherapy in Years 1-3 ($55,000 each year) and a second recruit, a drug discovery scientist, in Years 4-5 ($55,000 each year)

Public Health Relevance

The Hollings Cancer Center requests Developmental Funds from the Cancer Center Support Grant to fund pilot research projects and to recruit new faculty to MUSC;both endeavors will support the important goal of translational or

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA138313-04
Application #
8377238
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$244,314
Indirect Cost
$78,678

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Metelli, Alessandra; Salem, Mohammad; Wallace, Caroline H et al. (2018) Immunoregulatory functions and the therapeutic implications of GARP-TGF-? in inflammation and cancer. J Hematol Oncol 11:24
Helke, Kristi; Angel, Peggi; Lu, Ping et al. (2018) Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep 8:1627
DeHart, David N; Lemasters, John J; Maldonado, Eduardo N (2018) Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov 23:23-33
Scheffel, Matthew J; Scurti, Gina; Wyatt, Megan M et al. (2018) N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner. Cancer Immunol Immunother 67:691-702
Zunke, Friederike; Moise, Alexandra C; Belur, Nandkishore R et al. (2018) Reversible Conformational Conversion of ?-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron 97:92-107.e10
Schutt, Steven D; Wu, Yongxia; Tang, Chih-Hang Anthony et al. (2018) Inhibition of the IRE-1?/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. Blood Adv 2:414-427
Cartmell, Kathleen B; Mzik, Carlie R; Sundstrom, Beth L et al. (2018) HPV Vaccination Communication Messages, Messengers, and Messaging Strategies. J Cancer Educ :
King, Bill; Ndoen, Enjelita; Borland, Ron (2018) Smokers' risk perceptions and misperceptions of cigarettes, e-cigarettes and nicotine replacement therapies. Drug Alcohol Rev 37:810-817
Cartmell, Kathleen B; Young-Pierce, Jennifer; McGue, Shannon et al. (2018) Barriers, facilitators, and potential strategies for increasing HPV vaccination: A statewide assessment to inform action. Papillomavirus Res 5:21-31
Lin, Ching Ying; Kwon, Hyunwoo; Rangel Rivera, Guillermo O et al. (2018) Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma. Cancer Epidemiol Biomarkers Prev 27:1176-1185

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